DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://www.tandfonline.com/doi/full/10.1128/MCB.00337-09, but it redirected us to https://www.tandfonline.com/doi/full/10.1128/MCB.00337-09. The analysis below is for the second page.

Title[redir]:
Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock: Molecular and Cellular Biology: Vol 29 , No 24 - Get Access
Description:
The aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix/Per-Arnt-Sim homology superfamily and is involved in the induction of drug-metabolizing enzymes and the susceptibility ...

Matching Content Categories {📚}

Education
Science
Non-Profit & Charity

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

japan, sciences, access, tsukuba, science, journals, technology, article, research, open, taylor, francis, search, ahr, online, institute, studies, health, browse, journal, center, log, articles, find, environment, advanced, medical, agency, kawaguchi, group, page, publish, social, cart, read, issue, alliance, basic, university, tennoudai, sorst, honcho, pdf, information, register, molecular, mice, national, cancer, saitama,

Topics {✒️}

social care medicine basic medical sciences journals bioscience molecular ligand-activated transcription factor mechanism involving nf-κb bone marrow-derived macrophages increased il-1β secretion twitter page taylor downloaded article pdf health sciences enhanced il-1β secretion article /doi/full/10 induced septic shock aryl hydrocarbon rec francis group recent studies journal search calls cart search downloaded article pdfs advanced search molecular limited period find guidance endotoxin-induced death crossref citations journals books read lists articles solution oriented research receive personalised research access rights institution access published online cellular biology list jun kanno2 division katsuhide igarashi2 division toxicological effects caused polycyclic aromatic hydrocarbons applicable share back japan science citing articles based ahr directly regulates ahr nuclear translocator wild-type ahr journals browse issue 24 hypersensitivity open pai-2-expressing adenoviruses information lps-dependent manner technology agency science

Questions {❓}

00337-09?
Forgot password?
Why publish with us?

Schema {🗺️}

BreadcrumbList:
      context:https://schema.org
      itemListElement:
            type:ListItem
            position:1
            name:Home
            item:https://www.tandfonline.com/
            type:ListItem
            position:2
            name:All Journals
            item:https://www.tandfonline.com/action/showPublications?pubType=journal
            type:ListItem
            position:3
            name:Bioscience
            item:https://www.tandfonline.com/subjects/bioscience
            type:ListItem
            position:4
            name:Molecular and Cellular Biology
            item:https://www.tandfonline.com/tmcb20
            type:ListItem
            position:5
            name:List of Issues
            item:https://www.tandfonline.com/loi/tmcb20
            type:ListItem
            position:6
            name:Volume 29, Issue 24
            item:https://www.tandfonline.com/toc/tmcb20/29/24
            type:ListItem
            position:7
            name:Hypersensitivity of Aryl Hydrocarbon Rec ....
ListItem:
      position:1
      name:Home
      item:https://www.tandfonline.com/
      position:2
      name:All Journals
      item:https://www.tandfonline.com/action/showPublications?pubType=journal
      position:3
      name:Bioscience
      item:https://www.tandfonline.com/subjects/bioscience
      position:4
      name:Molecular and Cellular Biology
      item:https://www.tandfonline.com/tmcb20
      position:5
      name:List of Issues
      item:https://www.tandfonline.com/loi/tmcb20
      position:6
      name:Volume 29, Issue 24
      item:https://www.tandfonline.com/toc/tmcb20/29/24
      position:7
      name:Hypersensitivity of Aryl Hydrocarbon Rec ....
PublicationIssue:
      id:#issue
      issueNumber:24
      datePublished:2009-12-01
      isPartOf:
         id:#periodical
         type:
            PublicationVolume
            Periodical
         name:Molecular and Cellular Biology
         issn:
            1098-5549
         volumeNumber:29
         publisher:Taylor & Francis Group
["PublicationVolume","Periodical"]:
      id:#periodical
      name:Molecular and Cellular Biology
      issn:
         1098-5549
      volumeNumber:29
      publisher:Taylor & Francis Group
ScholarlyArticle:
      mainEntityOfPage:https://www.tandfonline.com/doi/full/10.1128/MCB.00337-09
      url:https://www.tandfonline.com/doi/full/10.1128/MCB.00337-09
      isPartOf:#periodical
      sameAs:https://doi.org/10.1128/MCB.00337-09
      identifier:10.1128/MCB.00337-09
      isAccessibleForFree:false
      articleSection:Article
      name:Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock
      headline:Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock
      abstract:Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Recent studies have revealed that AhR is involved in the normal development and homeostasis of many organs. Here, we demonstrate that AhR knockout (AhR KO) mice are hypersensitive to lipopolysaccharide (LPS)-induced septic shock, mainly due to the dysfunction of their macrophages. In response to LPS, bone marrow-derived macrophages (BMDM) of AhR KO mice secreted an enhanced amount of interleukin-1Î² (IL-1Î²). Since the enhanced IL-1Î² secretion was suppressed by supplementing Plasminogen activator inhibitor-2 (Pai-2) expression through transduction with Pai-2-expressing adenoviruses, reduced Pai-2 expression could be a cause of the increased IL-1Î² secretion by AhR KO mouse BMDM. Analysis of gene expression revealed that AhR directly regulates the expression of Pai-2 through a mechanism involving NF-ÎºB but not AhR nuclear translocator (Arnt), in an LPS-dependent manner. Together with the result that administration of the AhR ligand 3-methylcholanthrene partially protected mice with wild-type AhR from endotoxin-induced death, these results raise the possibility that an appropriate AhR ligand may be useful for treating patients with inflammatory disorders.
      description:Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Recent studies have revealed that AhR is involved in the normal development and homeostasis of many organs. Here, we demonstrate that AhR knockout (AhR KO) mice are hypersensitive to lipopolysaccharide (LPS)-induced septic shock, mainly due to the dysfunction of their macrophages. In response to LPS, bone marrow-derived macrophages (BMDM) of AhR KO mice secreted an enhanced amount of interleukin-1Î² (IL-1Î²). Since the enhanced IL-1Î² secretion was suppressed by supplementing Plasminogen activator inhibitor-2 (Pai-2) expression through transduction with Pai-2-expressing adenoviruses, reduced Pai-2 expression could be a cause of the increased IL-1Î² secretion by AhR KO mouse BMDM. Analysis of gene expression revealed that AhR directly regulates the expression of Pai-2 through a mechanism involving NF-ÎºB but not AhR nuclear translocator (Arnt), in an LPS-dependent manner. Together with the result that administration of the AhR ligand 3-methylcholanthrene partially protected mice with wild-type AhR from endotoxin-induced death, these results raise the possibility that an appropriate AhR ligand may be useful for treating patients with inflammatory disorders.
      author:
            type:Person
            name:Hiroki Sekine
            type:Person
            name:Junsei Mimura
            type:Person
            name:Motohiko Oshima
            type:Person
            name:Hiromi Okawa
            type:Person
            name:Jun Kanno
            type:Person
            name:Katsuhide Igarashi
            type:Person
            name:Frank J. Gonzalez
            type:Person
            name:Togo Ikuta
            type:Person
            name:Kaname Kawajiri
            type:Person
            name:Yoshiaki Fujii-Kuriyama
      pageStart:6391
      pageEnd:6400
      datePublished:2023-03-21
      publisher:
         type:Organization
         name:Taylor & Francis
         logo:
            type:ImageObject
            url:https://www.tandfonline.com/pb-assets/Images/Taylor_and_Francis_Group_Logo-1742461082.png
Person:
      name:Hiroki Sekine
      name:Junsei Mimura
      name:Motohiko Oshima
      name:Hiromi Okawa
      name:Jun Kanno
      name:Katsuhide Igarashi
      name:Frank J. Gonzalez
      name:Togo Ikuta
      name:Kaname Kawajiri
      name:Yoshiaki Fujii-Kuriyama
Organization:
      name:Taylor & Francis
      logo:
         type:ImageObject
         url:https://www.tandfonline.com/pb-assets/Images/Taylor_and_Francis_Group_Logo-1742461082.png
ImageObject:
      url:https://www.tandfonline.com/pb-assets/Images/Taylor_and_Francis_Group_Logo-1742461082.png

Social Networks {👍}(4)

External Links {🔗}(115)

Analytics and Tracking {📊}

Google Analytics
Google Analytics 4
Google Tag Manager
Google Universal Analytics
Hotjar

Libraries {📚}

Dropzone.js
jQuery

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Cookielaw
Optimizely
Pbgrd

2.96s.