
DOI . ORG {
}
Title[redir]:
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies | Science
Description:
TP53, which encodes the tumor suppressor p53, is the most frequently mutated gene in human cancer. The selective pressures shaping its mutational spectrum, dominated by missense mutations, are enig...
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Keywords {🔍}
science, crossref, web, pubmed, google, scholar, institute, cancer, usa, view, author, mutations, httpsorcidorg, articles, boston, harvard, medical, cell, university, massachusetts, technology, cambridge, missense, department, danafarber, broad, article, news, gene, data, oncology, myeloid, access, human, nat, mutant, authors, leukemia, aaas, issue, clinical, function, wang, foundation, research, division, hematology, brigham, womens, hospital,
Topics {✒️}
reviewers librarians manage /science-licenses-journal-article-reuse deep structure–function analysis authors information access report share empower tgfbeta-induced metastasis full text hla-a2-restricted neoepitopes partner internal medicine iii differential expression analysis germ-line mutant p53 s13 tables s1 current medical science mapk1/erk2 missense mutants dana-farber cancer institute social media facebook bcr-abl protein kinases dna-binding domain exert member current issue home science vol foundation medicine journals scholarly commentary wild-type p53 function blood-cancer risk inferred protein complex reveals acute myeloid leukemia hematopoietic lineage distribution org/0000-0001-5122-861x broad institute age-related clonal hematopoiesis dominant-negative effect dominant negative effect contents advertisement sign applied cancer science science news science google scholar instrumentarium science foundation p53-rescue therapy org/0000-0002-0359-978x broad institute dominant-negative inhibition science family account citation information cancer mutation pattern commentary permissions toc alerts check access p63 expression profiles complex cancer genomics authors contributed
Questions {❓}
- ALREADY A SUBSCRIBER OR AAAS MEMBER?
- Chan, Why are there hotspot mutations in the TP53 gene in human cancers?
- Sallman,Maximilian Stahl, TP53 -mutated acute myeloid leukemia: how can we improve outcomes?
- Should grant applicants judge competitors’ proposals?
- P53—still hazy after all these years?
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