
DOI . ORG {
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Title[redir]:
Skiing Toward Nonstop mRNA Decay | Science
Description:
Prokaryotic and eukaryotic cells have evolved remarkable quality assurance mechanisms at virtually every step of gene expression. One well-studied example in eukaryotes is nonsense-mediated messenger RNA (mRNA) decay (NMD). NMD prevents the synthesis of potentially deleterious truncated proteins when translation terminates prematurely (1). On pages 2258 and 2262 of this issue, the Dietz and Parker labs join forces to describe a new quality assurance mechanism that allows eukaryotes to identify and degrade mRNAs that lack a termination codon (2, 3).
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