
DOI . ORG {
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Title[redir]:
EGF promotes DKK1 transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3 | Science Signaling
Description:
The protein Dickkopf-1 (DKK1) is frequently overexpressed at the transcript level in hepatocellular carcinoma (HCC) and promotes metastatic progression through the induction of β-catenin, a Wnt sig...
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Keywords {🔍}
science, crossref, web, google, scholar, pubmed, dkk, cancer, hepatocellular, carcinoma, wang, cell, view, signaling, promotes, liu, hcc, china, university, henan, author, article, innovative, design, institute, school, pharmacy, jinming, ave, kaifeng, articles, drug, evaluation, histone, yang, pkm, news, phosphorylation, dickkopf, transcription, access, authors, cells, zhang, pathway, mol, acetylation, egfr, activation, expression,
Topics {✒️}
activating gsk-3β/β-catenin pathway β-catenin/mmp7 signaling pathway cytoplasmic/nuclear β-catenin accumulation reviewers librarians manage pi3k-akt pathway–dependent activation /science-licenses-journal-article-reuse recent advances molecular medicine wnt/β-catenin pathway disease–linked lrrk2-mutant mice tgf-β-induced emt jak/pi3k signaling pathway pi3k-akt pathway signaling mapk/erk-dependent pathway wnt positive-signaling loop pkm2/hif-1α axis interleukin-6-mediated functional upregulation authors information full text partner egfr-activated erk phosphorylated egfr-activated akt phosphorylated nf-κb p65 egf-egfr signalling pathway data analysis social media facebook growth factor axis targeting lrp6/wnt pathway authors contributed equally dkk1-knockdown huh-7 cells promotes metastatic progression promoted parallel mek-erk journals scholarly commentary song-qiang xie https pkm2-dependent phosphorylation science news wnt signaling effector pkm2 s37d mutant promotes tumor growth wnt signaling antagonist targeting dkk1 enhances real-time pcr science google scholar contents advertisement sign egf-induced increase member current issue akt-p300 pathway promotes gene transcription p300-dependent acetylation
Questions {❓}
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- Samant, Dickkopf1: A tumor suppressor or metastasis promoter?
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