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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
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  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
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We began analyzing https://www.biorxiv.org/content/10.1101/2020.08.18.256115v1, but it redirected us to https://www.biorxiv.org/content/10.1101/2020.08.18.256115v1. The analysis below is for the second page.

Title[redir]:
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation | bioRxiv
Description:
Osteoblasts orchestrate bone formation by secreting dense, highly cross-linked type I collagen and other proteins involved in osteogenesis. Mutations in Col1α1, Col1α2, or collagen biogenesis factors lead to the human genetic disease, osteogenesis imperfecta (OI). Herein, we show that the TENT5A gene, whose mutation is responsible for poorly characterized type XVIII OI, encodes an active cytoplasmic poly(A) polymerase regulating osteogenesis. TENT5A is induced during osteoblast differentiation and TENT5A KO osteoblasts are defective in mineralization. The TENT5A KO mouse recapitulates OI disease symptoms such as bone fragility and hypomineralization. Direct RNA sequencing revealed that TENT5A polyadenylates and increases expression of Col1α1 and Col1α2 RNAs, as well as those of other genes mutated in OI, resulting in lower production and improper folding of collagen chains. Thus, we have identified the specific pathomechanism of XVIII OI and report for the first time a biologically relevant post-transcriptional regulator of collagen production. We further postulate that TENT5A, possibly together with its paralogue TENT5C, is responsible for the wave of cytoplasmic polyadenylation of mRNAs encoding secreted proteins occurring during bone mineralization.

Matching Content Categories {📚}

  • Science
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  • Video & Online Content

Content Management System {📝}

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Website use Drupal 7 (http://drupal.org).

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

💥 Very Strong Traffic: 200k - 500k visitors per month


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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

biology, tenta, view, orcid, profile, bone, collagen, colα, medrxiv, subject, reviews, clinical, preprint, cytoplasmic, osteogenesis, biorxiv, university, genetics, trials, epidemiology, search, results, polyadenylation, formation, olga, pdf, osteoblasts, type, proteins, disease, responsible, xviii, mineralization, production, report, copyright, license, institute, technology, cancer, context, microbiology, papers, submitted, cookies, skip, main, content, homesubmitfaqblogalerts, rssresourcesaboutchannels,

Topics {✒️}

epidemiology subject categories clinical trials highly cross-linked type microbiology tent5a ko osteoblasts genetics biorxiv subject category epidemiology papers human genetic disease reviews author/funder keyword advanced search health-related information goretti aranaz novaliches monika kusio-kobiałka generous financial support chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior active cytoplasmic poly polymerase regulating osteogenesis context preprint cytoplasmic polyadenylation bone fragility xviii oi bone mineralization olga kofroňová proteins involved cytoplasmic polyadenylation tent5a gene tent5a polyadenylates collagen chains collagen production results follow bartosz tarkowski frantisek spoutil jakub gruchota marcin szpila aleksander chlebowski radislav sedlacek jan prochazka secreting dense osteogenesis imperfecta osteoblast differentiation increases expression genes mutated lower production improper folding specific pathomechanism

Social Networks {👍}(4)

External Links {🔗}(214)

Analytics and Tracking {📊}

  • Google Analytics
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Libraries {📚}

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Emails and Hosting {✉️}

Mail Servers:

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CDN Services {📦}

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