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Title[redir]:
Journal of Neuro-Ophthalmology
Description:
onsidered as a cause of optic neuritis (ON) associated with MS because immunization with MOG antigen derived from oligodendrocytes induces murine ON with myelitis. We investigated the relationship between NMO antibody (NMO-Ab) and anti-MOG antibody (MOG-Ab) and potential in patients with ON for recovery of vision. Methods: Thirty-three eyes of 23 patients with ON were studied. At presentation, serum NMO-Ab was measured by immunofluorescence using HEK 293 cells transfected with AQP4โGFP, and anti-MOG1โ125 antibody was measured by enzyme-linked immunosorbent assay. MOG-Ab seropositivity was defined by comparing with MOG-Ab level obtained from 8 healthy normal subjects. Results: Eleven (47%) of 23 ON patients were NMO-Ab seropositive, while 8 (34%) of the 23 patients were MOG-Ab seropositive. Six (26%) of 23 patients were seropositive for both NMO-Ab and MOG-Ab. Ten (43%) of 23 patients were seronegative for both antibodies. Three (50%) of 6 eyes of patients seropositive for both antibodies did not respond to corticosteroid pulse therapy and plasmapheresis, and visual acuity remained unchanged. In the NMO-Ab(โ)/MOG-Ab(โ) group, visual acuity improved significantly (P < 0.0001). In the other 3 groups (NMO-Ab(+)/MOG-Ab(+), NMO-Ab(+)/MOG-Ab(โ), and NMO-Ab(โ)/MOG-Ab(+)), visual acuity did not change significantly (P = 0.53, 0.42, and 0.45, respectively). Conclusion: NMO-Ab and MOG-Ab could be potential biomarkers to determine visual prognosis in patients with ON....
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Keywords {๐}
patients, nmoab, mogab, nmoabmogab, mog, visual, cells, seropositive, ngml, journal, optic, nmo, serum, aqp, antibody, healthy, antibodies, acuity, relationship, phd, myelin, cns, concentration, significant, antimog, antigen, corticosteroid, pulse, therapy, group, groups, controls, median, difference, issue, article, neuritis, neuromyelitis, optica, protein, considered, investigated, measured, results, acute, outcome, response, blood, samples, data,
Topics {โ๏ธ}
neuro-ophthalmology illustrated enzyme-linked immunosorbent assay full-length complementary dna neuro-ophthalmology 32 dna-encoding human aquaporin-4 tokyo medical university median mog-ab concentration nonpathogenic anti-mog antibodies nmo-ab titers correlate mog-ab remains unknown anti-mog1โ125 antibody mog-induced eae showed journal authors submit etoc alerts adult human cerebellum poor visual prognosis visual acuity outcome mog-specific antibodies directed subacute painful loss t-cell autoantigen mog-ab level obtained poor visual recovery antigen-presenting cells minor myelin antigen anti-aquaporin-4 antibody antiโmog antibody anti-mog antibody myelin oligodendrocyte glycoprotein average absorbance values visual field abnormality posttreatment visual acuity serum immunoglobulin autoantibody affected optic nerve peripheral blood lymphocytes ๏ฟฝcross-presentingโ mog myelin basic protein anti-mog-ab predominant water channel suggesting functional segregation methylprednisolone administered intravenously pulse steroid therapy clinically isolated syndrome hypothesis requires recruitment dural sinus thrombosis artificial intelligence training mog antigen derived peripheral blood cells anti-mog antibodies mog-ab seropositivity corticosteroid pulse therapy
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