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Title[redir]:
The American Journal of Surgical Pathology
Description:
specimens taken for other reasons. Their incidence has increased in the last 2 decades, and novel variants, including a pleomorphic type, have been described. Loss of E-cadherin expression is recognized as a hallmark diagnostic feature of LN and invasive lobular carcinomas, and immunohistochemical (IHC) analysis using anti-E-cadherin antibodies has been proven to be a useful method to differentiate between lobular and ductal lesions. The frequent use of E-cadherin IHC analysis in routine diagnostic histopathology, however, has resulted in confusion with regard to the actual value of IHC with antibodies against E-cadherin and other proteins of the cadherin-catenin complex. This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology....
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Keywords {🔍}
journal, phd, lobular, ecadherin, issue, frcpath, ihc, access, subscribe, alerts, authors, article, neoplasia, breast, invasive, expression, diagnostic, log, register, logo, articles, issues, abstract, sunil, mbbs, pathology, buy, carcinoma, lesions, immunohistochemical, analysis, antibodies, data, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, special, revisited, emphasis, role,
Topics {✒️}
anti-e-cadherin antibodies e-cadherin ihc analysis multiple endocrine neoplasia full text access authors journal info journal authors submit atypical lobular hyperplasia invasive lobular carcinomas hallmark diagnostic feature routine diagnostic histopathology chronic ulcerative colitis artificial intelligence training e-cadherin expression cadherin-catenin complex beta-catenin immunostaining invasive breast cancer invasive lobular carcinoma diagnostic breast pathology puay-hoon mbbs etoc alerts β catenin expression service request 800-638-3030 register subscribe individual subscribers log american journal journal tables e-cadherin issue lobular carcinoma β-catenin website subscribe breast revisited altered expression surgical pathology 37 center submit journal vincent-salomon reis-filho e1-e11 risk indicators nonobligate precursors pleomorphic type recent clinicopathologic molecular data read usefulness differential diagnosis primary adenocarcinoma email inbox rights reserved data mining
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