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Title[redir]:
The American Journal of Surgical Pathology
Description:
d human male genital tract. We report our findings of PAX8 and PAX2 expression in the epithelium of the normal male genital tract and in epithelial tumors derived therefrom using immunohistochemistry (IHC). We found that PAX8 and PAX2 were expressed in the epithelium of the male genital tract from the rete testis to the ejaculatory duct. Rare glands in the prostatic central zone, a tissue of purported Wolffian duct origin, were focally positive for PAX2, but no PAX8 was detected in this area, a finding that may warrant further study. We found diffuse expression of PAX8 and PAX2 in 1 case each of serous cystadenoma of the epididymis, carcinoma of the rete testis, Wolffian adnexal tumor of the seminal vesicle, and endometrioid carcinoma of the seminal vesicle. Neither PAX8 nor PAX2 was detected in the seminiferous tubules and interstitium of the normal testis, nor in Leydig cell tumors (n=6), Sertoli cell tumors (n=2), or 48 of 49 germ cell tumors. One pediatric yolk sac tumor showed focal and weak staining for PAX8. Tumors of mesothelial origin, that is, adenomatoid tumors (n=3) and peritoneal malignant mesotheliomas (n=37) in men, were negative for PAX2 and PAX8. Neither PAX2 nor PAX8 was present in other areas of the prostate. Expression of PAX8 and PAX2 in these primary epithelial neoplasms of the male genital tract is due to their histogenetic relationship with Wolffian or Müllerian ducts. PAX8 and PAX2 IHC may facilitate the diagnosis of these tumors and should be included in the differential diagnostic IHC panel....
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Keywords {🔍}
pax, journal, tumors, male, genital, tract, wolffian, issue, phd, expression, carcinoma, cell, access, subscribe, alerts, articles, authors, abstract, epithelial, müllerian, origin, ihc, testis, log, register, logo, issues, diagnosis, primary, neoplasms, lorenzo, cristina, pathology, buy, ducts, diagnostic, epithelium, normal, found, rete, duct, detected, study, tumor, seminal, vesicle, copyright, wolters, kluwer, health,
Topics {✒️}
cell-lineage-specific transcription factors male genital tract wolffian adnexal tumor specific diagnostic markers journal authors submit full text access primary epithelial neoplasms leydig cell tumors sertoli cell tumors prostatic central zone peritoneal malignant mesotheliomas breast pseudocarcinomatous hyperplasia cronkhite-canada polyps juvenile polyposis back artificial intelligence training etoc alerts guo-xia md service request 800-638-3030 pax2 immunostaining facilitates register subscribe individual subscribers log found diffuse expression american journal journal tables ejaculatory duct issue normal testis website subscribe müllerian origin mesothelial origin journal endometrioid carcinoma tubulolobular carcinoma center submit adenomatoid tumors hamele-bena magi-galluzzi oliver-krasinski müllerian ducts recently emerged rete testis rare glands focally positive serous cystadenoma seminal vesicle seminiferous tubules weak staining histogenetic relationship rights reserved pure tubular
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