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Title[redir]:
Current Opinion in Lipidology
Description:
k and what impact therapies may have. Recent findings Atherosclerosis is more prevalent and accelerated in both conditions. Indeed the process may actually precede the onset of clinical inflammatory disease. Metabolic alterations include insulin resistance and the generation of proinflammatory HDL. In addition, inflammatory mechanisms central to both rheumatoid arthritis and systemic lupus erythematosus such as macrophage activation, interferon-1 and complement deficiency may contribute to atherogenesis. There is still no consensus as to the value of primary preventive strategies in these conditions. However, drugs such as hydroxychloroquine seem to modify coronary heart disease risk and may improve survival. The recently developed antitumour necrosis factor drugs may also reduce coronary heart disease risk but biomarker studies to date have been inconclusive. Summary There is an urgent need for clinical trials to examine both the lipid-lowering and inflammatory hypotheses of atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Novel targeted therapies in development may also have a major impact on future coronary heart disease risk in these conditions....
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Keywords {🔍}
journal, disease, risk, issue, atherosclerosis, rheumatoid, arthritis, systemic, lupus, erythematosus, coronary, heart, access, subscribe, alerts, authors, abstract, conditions, inflammatory, log, register, logo, articles, issues, current, buy, review, recent, studies, increased, examine, impact, therapies, clinical, drugs, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous, hyperlipidaemia,
Topics {✒️}
coronary heart disease journal authors submit full text access systemic lupus erythematosus clinical inflammatory disease primary preventive strategies artificial intelligence training inflammatory mechanisms central etoc alerts review recent studies service request 800-638-3030 register subscribe individual subscribers log journal tables cardiovascular disease increased risk issue abstract hyperlipidaemia website subscribe journal inflammatory hypotheses biomarker studies clinical trials center submit rheumatoid arthritis ian na inflammation mediates impact therapies proinflammatory hdl macrophage activation complement deficiency improve survival lipid-lowering targeted therapies major impact email inbox rights reserved data mining durrington atherosclerosis drugs authors content log review subscribers text atherosclerosis edited paul sahenaa
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