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Title[redir]:
Current Opinion in Lipidology
Description:
e A desaturase 1 in health and disease. Recent findings Scd1-deficient mice have reduced lipid synthesis and enhanced lipid oxidation, thermogenesis and insulin sensitivity in various tissues including liver, muscle and adipose tissue due to transcriptional and posttranscriptional effects. These metabolic changes protect Scd1-deficient mice from a variety of dietary, pharmacological and genetic conditions that promote obesity, insulin resistance and hepatic steatosis. Stearoyl-coenzyme A desaturase 1 is required to guard against dietary unsaturated fat deficiency, leptin deficiency-induced diabetes, and palmitate-induced lipotoxic insults in muscle and pancreatic Ξ²-cells. Paradoxical observations of increased muscle stearoyl-coenzyme A desaturase 1 during obesity, starvation and exercise raise questions as to the role of stearoyl-coenzyme A desaturase 1 in this tissue. Mice with a liver-specific loss of stearoyl-coenzyme A desaturase 1, and inhibition of stearoyl-coenzyme A desaturase 1 via antisense or RNA interference, recapitulate only a subset of the phenotypes observed in global Scd1 deficiency, indicating the involvement of multiple tissues. Summary Recent studies in humans and animal models have highlighted that modulation of stearoyl-coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly influences several facets of energy metabolism to affect susceptibility to obesity, insulin resistance, diabetes and hyperlipidemia....
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Keywords {π}
desaturase, stearoylcoenzyme, journal, issue, lipid, metabolism, access, subscribe, alerts, authors, abstract, role, mice, insulin, muscle, dietary, obesity, log, register, logo, articles, issues, current, buy, review, fatty, synthesis, health, recent, scddeficient, tissues, tissue, genetic, resistance, deficiency, diabetes, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous,
Topics {βοΈ}
palmitate-induced lipotoxic insults protect scd1-deficient mice leptin deficiency-induced diabetes increased muscle stearoyl-coenzyme global scd1 deficiency journal authors submit full text access monounsaturated fatty acids enhanced lipid oxidation pancreatic Ξ²-cells exercise raise questions liver-specific loss artificial intelligence training tissues including liver reduced lipid synthesis adipose tissue due etoc alerts service request 800-638-3030 reviewΒ stearoyl-coenzyme register subscribe individual subscribers log journal tables issue genetic conditions website subscribe journal stearoyl-coenzyme review evaluates multiple tissues energy metabolism center submit dietary intervention key regulator latest advances health insulin sensitivity posttranscriptional effects insulin resistance hepatic steatosis paradoxical observations rna interference phenotypes observed animal models affect susceptibility email inbox rights reserved data mining cohn role pivotal role desaturase 1 activity
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