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Title[redir]:
Current Opinion in Hematology
Description:
ial for the study of how aberrant transcriptional programming leads to lymphomagenesis and development of targeted antilymphoma therapy. Recent findings Identification of B-cell lymphoma 6 target genes indicates a critical role for B-cell lymphoma 6 in facilitating a state of physiological genomic instability required for germinal center B cells to undergo affinity maturation, and suggests its contribution to several additional cellular functions. The discovery of several layers of counterregulatory mechanisms reveals how B cells can control and fine-tune the potentially lymphomagenic actions of B-cell lymphoma 6. From the biochemical standpoint, B-cell lymphoma 6 can regulate distinct biological pathways through different cofactors. This observation explains how the biological actions of B-cell lymphoma 6 can be physiologically controlled through separate mechanisms and affords the means for improved therapeutic targeting. The fact that patients with B-cell lymphoma 6-dependent lymphoma can be identified on the basis of gene signatures suggests that therapeutic trials of B-cell lymphoma 6 inhibitors could be personalized to these individuals. Summary B-cell lymphoma 6 plays a fundamental role in lymphomagenesis and is an excellent therapeutic target for development of improved antilymphoma therapeutic regimens....
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Keywords {🔍}
bcell, lymphoma, journal, issue, therapeutic, access, subscribe, alerts, authors, abstract, center, cells, log, register, logo, articles, issues, current, buy, transcriptional, germinal, lymphomagenesis, development, antilymphoma, target, role, suggests, mechanisms, actions, biological, improved, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous, lymphoid, biology, diseases, edited, nancy,
Topics {✒️}
b-cell lymphoma 6 b-cell lymphomas journal authors submit excellent therapeutic target full text access targeted antilymphoma therapy improved therapeutic targeting commonly involved oncogene undergo affinity maturation additional cellular functions artificial intelligence training counterregulatory mechanisms reveals potentially lymphomagenic actions gene signatures suggests etoc alerts service request 800-638-3030 register subscribe individual subscribers log journal tables issue biological actions therapeutic trials website subscribe journal separate mechanisms center submit molecular pathogenesis jose mb sustained expression malignant transformation germinal center critical role fine-tune biochemical standpoint observation explains physiologically controlled fundamental role email inbox rights reserved data mining authors content log suggests subscribers text diseases edited weimina polo
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