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We began analyzing https://journals.lww.com/co-hematology/abstract/2008/01000/idiosyncratic_drug_induced_agranulocytosis_or.4.aspx, but it redirected us to https://journals.lww.com/co-hematology/abstract/2008/01000/idiosyncratic_drug_induced_agranulocytosis_or.4.aspx. The analysis below is for the second page.

Title[redir]:
Current Opinion in Hematology
Description:
the last 20 years, the incidence of idiosyncratic drug-induced agranulocytosis or acute neutropenia has remained stable at 2.4–15.4 cases per million, despite the emergence of new causative drugs: antibiotics (β-lactam and cotrimoxazole), antiplatelet agenst (ticlopidine), antithyroid drugs, sulfasalazine, neuroleptics (clozapine), antiepileptic agents (carbamazepine), nonsteroidal anti-inflammatory agents and dipyrone. Drug-induced agranulocytosis remains a serious adverse event due to the occurrence of severe sepsis with severe deep infections (such as pneumonia), septicemia and septic shock in around two thirds of patients. In this setting, old age (>65 years), septicemia or shock, metabolic disorders such as renal failure, and a neutrophil count under 0.1 × 109/l are poor prognostic factors. Nevertheless with appropriate management using preestablished procedures, with intravenous broad-spectrum antibiotic therapy and hematopoietic growth factors, the mortality rate is currently around 5%. Summary Given the increased life expectancy and subsequent longer exposure to drugs, as well as the development of new agents, healthcare professionals should be aware of this adverse event and its management....

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  • Health & Fitness
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  • Science

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What CMS is doi.org built with?


Doi.org is powered by MYBB.

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🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 76,504,851 visitors per month in the current month.

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Keywords {🔍}

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Topics {✒️}

idiosyncratic drug-induced agranulocytosis drug-induced agranulocytosis remains nonsteroidal anti-inflammatory agents journal authors submit full text access experience life-threatening poor prognostic factors hematopoietic growth factors increased life expectancy subsequent longer exposure artificial intelligence training adverse event resulting adverse event due etoc alerts severe deep infections service request 800-638-3030 register subscribe individual subscribers log journal tables issue adverse event website subscribe journal acute neutropenia severe neutropenia fatal infections center submit antiepileptic agents severe sepsis neutrophil count recent findings remained stable β-lactam antiplatelet agenst metabolic disorders renal failure preestablished procedures mortality rate healthcare professionals email inbox rights reserved data mining causative drugs antithyroid drugs septic shock authors content agents log subscribers

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External Links {🔗}(57)

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Emails and Hosting {✉️}

Mail Servers:

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