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Title[redir]:
European Journal of Gastroenterology & Hepatology
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have investigated this hypothesis, using dietary information collected from food diaries. The aim of this study was to investigate the total dietary intake of n-3 PUFAs and the specific n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the risk of developing incident UC. Methodology Twenty-five thousand six hundred and thirty-nine participants, living in Norfolk UK, aged 45β74 years (median age at recruitment of 59.2 years), completed 7-day food diaries. These were interpreted using a computer programme, which converted food items into nutrients, including n-3 PUFAs. The cohort was monitored for participants who developed UC. Each case was matched with four controls and an analysis performed using conditional logistic regression. Results In the cohort, 22 incident cases of UC were identified after a median follow-up time of 4.2 years (range 1.8β8.3 years). A statistically significant protective odds ratio (OR) for the trend across tertiles was found for DHA [ORβ=β0.43, 95% confidence interval (CI)=0.22β0.86, Pβ=β0.02] and borderline statistically significant differences for trends for total total n-3 PUFAs (ORβ=β0.56, 95% CI=0.28β1.13, Pβ=β0.10) and EPA (ORβ=β0.53, 95% CI=0.27β1.03, Pβ=β0.06) after adjusting for age, sex, total energy intake, smoking, and other fatty acids. Conclusion Total dietary n-3 PUFAs, EPA, and DHA, particularly DHA were associated with protection from UC in a cohort aged over 45 years. If the association is causal, then increasing the population
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Keywords {π}
journal, pufas, dietary, cohort, total, years, issue, dha, risk, access, subscribe, alerts, submit, articles, authors, abstract, bowel, disease, fatty, acids, food, intake, epa, log, register, logo, issues, polyunsaturated, aetiology, ulcerative, colitis, prospective, study, information, buy, protective, diaries, acid, incident, participants, aged, median, age, statistically, significant, text, subscribers, request, article, inflammatory,
Topics {βοΈ}
inflammatory bowel disease dietary information collected fatty acids total dietary intake journal authors submit full text access prospective cohort studies specific n-3 pufas including n-3 pufas total energy intake converted food items conditional logistic regression oral contraceptives increases artificial intelligence training service request 800-638-3030 developing incident uc register subscribe individual subscribers log journal tables dietary habits n-3 pufas n-6 pufas food diaries norfolk uk etoc alerts website subscribe journal center submit 22 incident cases cohort aged ulcerative colitis subodha shakyab kay-teed largely unknown metabolites derived eicosapentaenoic acid docosahexaenoic acid methodologyΒ twenty computer programme analysis performed median follow 95% confidence interval oily fish read exposure email inbox rights reserved data mining issue developed uc prevent uc
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