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Title[redir]:
Journal of Cardiovascular Pharmacology
Description:
diac injury. The reversible blockade of electron transport during ischemia prevents damage to mitochondria. We propose that the targets of PC cytoprotective signaling are mitochondria damaged by ischemia. Thus, if ischemia-mediated mitochondrial damage is prevented, PC at the onset of reperfusion will not result in additional protection. Isolated, Langendorff-perfused adult rat hearts underwent 25-minute global ischemia and 30-minute reperfusion. Amobarbital (2.5 mM) was used to reversibly inhibit electron transport during ischemia. PC (6 cycles of 10-second ischemia–reperfusion) was applied at the onset of reperfusion. Subsarcolemmal and interfibrillar mitochondria were isolated after reperfusion. Blockade of electron transport with amobarbital only during ischemia preserved oxidative phosphorylation and decreased myocardial injury. PC, after untreated ischemia, decreased cardiac injury without improvement of oxidative phosphorylation. Blockade of electron transport during ischemia or PC improved calcium tolerance and inner membrane potential in subsarcolemmal mitochondria after reperfusion. In hearts treated with amobarbital before ischemia, PC did not provide further protection. Thus, PC protects myocardium via the regulation of ischemia-damaged mitochondria during early reperfusion....
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Keywords {🔍}
journal, reperfusion, ischemia, mitochondria, electron, transport, issue, cardiac, injury, access, subscribe, alerts, authors, ischemiadamaged, damage, blockade, amobarbital, log, register, articles, issues, abstract, article, postconditioning, phd, buy, mitochondrial, applied, early, onset, protection, isolated, hearts, minute, subsarcolemmal, oxidative, phosphorylation, decreased, text, subscribers, request, browse, content, submit, service, privacy, policy, logo, advanced, search,
Topics {✒️}
ischemia-mediated mitochondrial damage journal authors submit ischemia-damaged mitochondria full text access decreases cardiac injury decrease cardiac injury decreased cardiac injury ischemia prevents damage ischemic postconditioning decreased myocardial injury artificial intelligence training mitochondria damaged pc cytoprotective signaling pc protects myocardium etoc alerts hearts treated service request 800-638-3030 journal tables register subscribe 30-minute reperfusion individual subscribers log article oxidative phosphorylation untreated ischemia electron transport interfibrillar mitochondria issue journal authors ischemia–reperfusion subsarcolemmal mitochondria damage persists website subscribe center submit melanie bs† ying ba cardiovascular pharmacology 59 finding suggests membrane potential email inbox rights reserved data mining ischemia qun md heng md mitochondria reperfusion chen ludovic phd† early reperfusion additional protection
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