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Title[redir]:
Journal of Cardiovascular Pharmacology
Description:
rich, and the loss of linoleic acid content is associated with cardiac disorders including ischemia and reperfusion, heart failure, and diabetes, as well as the X-linked recessive disease, Barth syndrome. To attain its high levels of linoleic acid, newly synthesized CL must initially undergo remodeling. CL modification and depletion by pathological processes may represent a failure of this remodeling pathway or activation of an alternative โpathological remodelingโ pathway that causes the substitution of higher molecular weight, polyunsaturated fatty acyl side chains such as arachidonic or docosahexaenoic acid onto CL. This remodeling may occur in response to the alteration of CL by oxidative mechanisms, but the substituted side chains can also provoke further oxidation of CL. It is increasingly thought that cardiac pathology may result, at least partially, due to changes in CL resulting from the pathological remodeling process. Dietary interventions may restore CL to its linoleic acid-rich form and improve cardiac function by redirecting the remodeling process....
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Keywords {๐}
journal, remodeling, issue, linoleic, acid, access, subscribe, alerts, authors, abstract, heart, content, cardiac, pathological, log, register, articles, issues, article, cardiolipin, buy, mitochondrial, function, failure, pathway, side, chains, process, text, subscribers, request, browse, submit, service, privacy, policy, logo, advanced, search, podcast, info, previous, invited, review, sparagna, genevieve, phd, lesnefsky, edward, author,
Topics {โ๏ธ}
x-linked recessive disease linoleic acid-rich form substituted side chains journal authors submit full text access linoleic acid rich electron transport chain initially undergo remodeling higher molecular weight artificial intelligence training linoleic acid content pathological remodeling process improve cardiac function newly synthesized cl etoc alerts service request 800-638-3030 register subscribe individual subscribers log journal tables remodeling pathway linoleic acid remodeling process issue pathological processes cardiac pathology website subscribe docosahexaenoic acid journal center submit cardiovascular pharmacology 53 mitochondrial phospholipid fundamentally contributes mitochondrial membrane actively involved barth syndrome high levels oxidative mechanisms increasingly thought dietary interventions email inbox rights reserved data mining heart sparagna functional cl cl modification cl resulting restore cl article heart failure remodeling
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