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Title[redir]:
Behavioural Pharmacology
Description:
t treatments. Brain-derived neurotrophic factor and other neurotrophic/growth factors are decreased in postmortem hippocampal tissue from suicide victims, which suggests that altered trophic support could contribute to the pathophysiology of MDD. Preclinical studies demonstrate that exposure to stress leads to atrophy and cell loss in the hippocampus as well as decreased expression of neurotrophic/growth factors, and that antidepressant administration reverses or blocks the effects of stress. Accumulating evidence suggests that altered neurogenesis in the adult hippocampus mediates the action of antidepressants. Chronic antidepressant administration upregulates neurogenesis in the adult hippocampus and this cellular response is required for the effects of antidepressants in certain animal models of depression. Here, we review cellular (e.g. adult neurogenesis) and behavioral studies that support the neurotrophic/neurogenic hypothesis of depression and antidepressant action. Aberrant regulation of neuronal plasticity, including neurogenesis, in the hippocampus and other limbic nuclei may result in maladaptive changes in neural networks that underlie the pathophysiology of MDD....
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Keywords {π}
journal, neurogenesis, antidepressant, hippocampus, issue, adult, access, subscribe, alerts, submit, articles, authors, abstract, factors, hippocampal, mdd, depression, log, register, logo, issues, review, neurotrophic, treatments, animal, models, buy, limbic, including, atrophy, neurotrophicgrowth, decreased, suggests, altered, support, pathophysiology, studies, stress, administration, effects, action, antidepressants, cellular, text, subscribers, request, browse, content, service, privacy,
Topics {βοΈ}
brain-derived neurotrophic factor journal authors submit antidepressant administration reverses full text access neurotrophic/neurogenic hypothesis artificial intelligence training neurotrophic/growth factors postmortem hippocampal tissue preclinical studies demonstrate accumulating evidence suggests adult hippocampal neurogenesis altered trophic support service request 800-638-3030 adult hippocampus mediates register subscribe individual subscribers log journal tables neurotrophic factors etoc alerts altered neurogenesis adult neurogenesis website subscribe antidepressant treatments journal center submit review cellular behavioral studies antidepressant action including neurogenesis hippocampal atrophy adult hippocampus animal models behavior schmidt limbic structures regulate mood cognitive functions suicide victims cell loss cellular response aberrant regulation neuronal plasticity limbic nuclei neural networks email inbox rights reserved data mining issue depressive stress leads decreased expression
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