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  3. CMS
  4. Monthly Traffic Estimate
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We began analyzing https://journals.lww.com/immunotherapy-journal/abstract/2010/04000/preclinical_evaluation_of_a_recombinant.4.aspx, but it redirected us to https://journals.lww.com/immunotherapy-journal/abstract/2010/04000/preclinical_evaluation_of_a_recombinant.4.aspx. The analysis below is for the second page.

Title[redir]:
Journal of Immunotherapy
Description:
rated an anti-PSMA single-chain antibody fragment (scFv), called D7, by phage display from the monoclonal antibody 3/F11. By C-terminal ligation of the toxic domain of Pseudomonas Exotoxin A (PE40) to the genes of D7, the immunotoxin D7-PE40 was generated. D7 and D7-PE40 specifically bound to PSMA transfectants and to the PSMA expressing prostate cancer cell line C4-2. In addition, D7-PE40 showed a high serum stability and induced a 50% reduction of viability (IC50) in C4-2 cells at a concentration of 140 pM. In vivo, D7-PE40 was well tolerated in SCID mice up to a single dose of 20 μg, whereas higher doses induced severe hepatotoxicity with deaths of the animals. Immunotoxin treatment of mice bearing C4-2 tumor xenografts caused a significant inhibition of tumor growth, whereas mice with PSMA-negative DU 145 tumors remained unaffected. Owing to its high and specific cytotoxicity and its capability to inhibit prostate tumor growth in vivo the immunotoxin D7-PE40 represents a promising candidate for the immunotherapy of prostate cancer....

Matching Content Categories {πŸ“š}

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  • Education
  • Science

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Doi.org is powered by MYBB.

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🌍 Impressive Traffic: 500k - 1M visitors per month


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Keywords {πŸ”}

journal, prostate, cancer, dpe, issue, immunotoxin, tumor, access, subscribe, alerts, authors, abstract, specific, antigen, immunotherapy, psma, mice, log, register, logo, articles, issues, membrane, singlechain, wetterauer, buy, cells, generated, antibody, high, induced, vivo, growth, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, rosenberg, interview, info, previous, basic,

Topics {βœ’οΈ}

prostate-specific membrane antigen immunotoxin d7-pe40 represents d7-pe40 specifically bound 0b013e3181c5495c buy abstract monoclonal antibody 3/f11 full text access immunotoxin d7-pe40 journal authors submit c-terminal ligation artificial intelligence training d7-pe40 showed etoc alerts high serum stability c4-2 cells prostate cancer single dose service request 800-638-3030 register subscribe individual subscribers log journal tables immunotoxin treatment tumor growth psma transfectants specific cytotoxicity issue specific immunotherapy tumor progression d7-pe40 scid mice website subscribe journal antigen called d7 center submit psma elsΓ€sser-beile abundantly expressed expression correlates therapeutic option phage display toxic domain pseudomonas exotoxin significant inhibition promising candidate email inbox rights reserved data mining induced mice content

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Analytics and Tracking {πŸ“Š}

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Libraries {πŸ“š}

  • Bootstrap
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Emails and Hosting {βœ‰οΈ}

Mail Servers:

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