
DOI . ORG {
}
Detected CMS Systems:
- MyBB (1 occurrences)
Title[redir]:
Transplantation
Description:
unction of T cells, B cells, and natural killer cells. These unique properties make MSC of great interest for clinical applications in tissue engineering and immunosuppression. Underlying the MSC-mediated immunomodulatory mechanisms is a nonspecific antiproliferative effect, which is the consequence of cyclin D2 inhibition. Of special interest are the molecular mechanisms, by which MSC influence their target cells. Several studies have been conducted in this field, and the current data suggest roles for indoleamine 2,3-dioxygenase, prostaglandin E2, nitric oxide, histocompatibility locus antigen-G, insulin-like growth factor-binding proteins, and tolerogenic antigen-presenting cells. Understanding these mechanisms is crucial for future use of MSC in research and clinical applications....
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Doi.org is built with MYBB.
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🌍 Impressive Traffic: 500k - 1M visitors per month
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Keywords {🔍}
msc, cells, cell, proliferation, stem, effect, mesenchymal, immunosuppressive, inhibition, tcell, journal, mechanisms, allogeneic, shown, growth, class, ifnγ, effects, function, human, expression, vitro, immunomodulation, activated, tryptophan, hlag, issue, properties, differentiation, immunomodulatory, nitric, oxide, molecules, capable, immune, inhibitory, presence, inhibit, demonstrated, soluble, article, hematopoietic, clinical, applications, immunosuppression, antiproliferative, cyclin, studies, data, indoleamine,
Topics {✒️}
n-nitro-l-arginine methyl ester control t-cell responses msc-mediated t-cell inhibition growth factor-binding proteins nk cell-mediated cytotoxicity regulating b-cell expression professional antigen-presenting cells ido-inhibitor 1-methyl-tryptophan tolerogenic antigen-presenting cells anti-cd40 monoclonal antibody inhibit b-cell proliferation hla class i-negative interleukin-4-mediated th2-response allogeneic t-cell response suppressing t-cell proliferation ido-mediated tryptophan depletion t-cell activation soluble isoform hla-g5 journal authors submit msc-mediated immunomodulatory mechanisms histocompatibility locus antigen histocompatibility locus antigen superantigen staphylococcal enterotoxin multipotent progenitor cell tryptophan degradation mediated t-cell proliferation mesenchymal stem cells powerful immunomodulatory effects ectodermal cell lineages cellular therapy suggested b-cell proliferation dendritic cells diminished interesting cell type scientific investigation due direct cross-talk adding exogenous tryptophan exogenous tryptophan replacement candidate mechanism involves mixed lymphocyte cultures th2 cytokine profile producing reduced levels tnf-α da silva- meirelles artificial intelligence training immune-mediated disorders exact molecular pathways parenchymal stem cells initial data suggested multipotent progenitor cells msc strongly inhibit
Questions {❓}
- WHICH CELLS OF THE IMMUNE SYSTEM ARE MODULATED IN THEIR FUNCTION BY MSC?
- WHICH MECHANISMS ARE INVOLVED INTO THE IMMUNOMODULATION BY MSC?
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