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Title[redir]:
JAIDS Journal of Acquired Immune Deficiency Syndromes
Description:
fection on distinct subsets of CD16+ monocytes. Methods: Untreated HIV-infected patients were recruited to investigate the relationship between the proportions of monocyte subsets with plasma viral loads and CD4+ T-cell counts. Patients receiving highly active antiretroviral therapy (HAART) were followed up in a cross-sectional and a longitudinal study. Results: Compared with CD14lowCD16+, CD14highCD16+ monocytes showed higher levels of CD64 and HLA-DR antigens, which imply that these 2 distinct subsets have different immunoregulatory phenotypes. In HAART-naive patients, elevated proportions of CD14highCD16+ monocytes were correlated with increased viral loads and decreased CD4+ T-cell counts, whereas CD14lowCD16+ monocytes did not show such correlation with disease progression. Of importance, HAART recovered the proportion of CD14highCD16+ monocytes, whereas CD14lowCD16+ monocytes did not decrease during 1 year of antiviral therapy. Conclusions: Taken together, our observations elucidate distinct immune responses of monocyte subsets during HIV infection and antiviral therapy and provide new insight into the roles of innate immunity in HIV-related pathogenesis....
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Keywords {🔍}
journal, monocytes, cdhighcd, cdlowcd, subsets, issue, patients, access, subscribe, alerts, authors, abstract, hivinfected, hiv, distinct, therapy, log, register, logo, articles, issues, disease, progression, han, phd, zhao, bsc, mph, immune, buy, cdcd, infection, proportions, monocyte, viral, loads, tcell, counts, haart, antiviral, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary,
Topics {✒️}
cd4+ t-cell counts untreated hiv-infected patients journal authors submit hiv-infected individuals full text access haart-naive patients important cellular target plasma viral loads hla-dr antigens increased viral loads hiv-related pathogenesis artificial intelligence training cd14+cd16+ monocytes etoc alerts cd14lowcd16+ monocytes correlate service request 800-638-3030 register subscribe individual subscribers log journal tables issue beibei phd† cd14highcd16+ monocytes antiviral therapy cd16+ monocytes journal hiv-1 entry hiv infection distinct subsets 2 distinct subsets website subscribe cd14lowcd16+ monocytes center submit disease progression junyan msc† ning md† yan md‡ chuan bsc xin bsc yu md fujie md hongxin md hui md peripheral blood heterogeneous population cd14lowcd16+ subsets monocyte subsets cross-sectional longitudinal study immunoregulatory phenotypes haart recovered
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