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The American Journal of Surgical Pathology
Description:
e retrospectively assessed 334 cases from 2002 to 2007 and correlated pathologic findings with chemotherapy use and perioperative course. Features of fatty liver disease were graded according to established schemes, and several features of vascular injury, including sinusoidal dilation, nodular regenerative hyperplasia and parenchymal extinction lesions (PELs), were also scored semiquantitatively and a combined vascular injury (CVI) score was determined. Moderate and severe fatty injury was uncommon with steatohepatitis detected in 8 cases (2.4%), 7 of whom did not receive chemotherapy. Multivariate analysis showed steatosis greater than 33% and steatohepatitis were independently associated with Body Mass Index of 30 or more (P<0.001) but not chemotherapy. Vascular injuries were detected in 117 cases, were significantly associated with oxaliplatin, and the combined assessment of vascular features (a CVI score of 3 or more) was more strongly associated with oxaliplatin (P=0.0004) than any one feature in isolation. Perioperative outcome was not associated with parenchymal injury or preoperative chemotherapy. We conclude that although CASH is uncommon in this population vascular injury is frequently seen in resection specimens, but pathologic examination limited to sinusoidal dilation misses the majority of these. Semiquantitative measurement enables reproducible assessment of vascular injuries, allows comparison between studies, and may help inform future treatment decisions in patients with limited hepatic reserve....
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Keywords {🔍}
journal, injury, vascular, liver, chemotherapy, issue, steatohepatitis, parenchymal, access, subscribe, alerts, articles, authors, abstract, preoperative, oxaliplatin, cases, features, log, register, logo, issues, colorectal, cancer, semiquantitative, analysis, specimens, buy, resection, cash, pathologic, perioperative, fatty, sinusoidal, dilation, combined, cvi, score, uncommon, detected, injuries, assessment, limited, text, subscribers, request, browse, content, submit, service,
Topics {✒️}
semiquantitative histologic analysis fatty liver disease parenchymal liver injury journal authors submit metastatic colorectal cancer full text access severe fatty injury newer chemotherapeutic agents correlated pathologic findings including sinusoidal dilation nodular regenerative hyperplasia body mass index pathologic examination limited sinusoidal dilation misses limited hepatic reserve artificial intelligence training parenchymal extinction lesions population vascular injury vascular parenchymal injury carol-anne md etoc alerts combined vascular injury service request 800-638-3030 register subscribe individual subscribers log american journal journal tables combined assessment parenchymal injury issue vascular injury website subscribe preoperative chemotherapy journal resection specimens center submit receive chemotherapy vascular injuries preoperative irinotecan paul md sulaiman md† aaron md malcolm md† steven md‡ maha md surgical pathology 34 established schemes scored semiquantitatively email inbox rights reserved
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