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Title[redir]:
Obstetrical & Gynecological Survey
Description:
molecular research to focus mainly on these organs, giving less attention to all other systemic effects. The aim of this review was to evaluate all described systemic effects of raloxifene, investigating its molecular and tissutal mechanism of action. A literature research was carried out in electronic databases MEDLINE, EMBASE, ScienceDirect, and the Cochrane Library in interval time between 2000 and 2012. Outcomes were considered in relation to positive/adverse effects concerning bone metabolism, lipid metabolism, coagulation pattern, menopausal symptoms, breast cancer onset, and endometrial cancer onset. Raloxifene acts as an estrogen agonist or antagonist depending on the tissue. This feature is related to specific actions on at least 2 distinct estrogen receptors, whose proportions vary according to tissue type. Raloxifene is a drug for the treatment of osteoporosis and for the prevention of estrogen receptor–positive breast cancer because it guarantees a safety profile on the endometrium. Raloxifene is furthermore an effective therapy in women with increased levels of plasma cholesterol. Raloxifene treatment shifts the coagulation pattern toward prothrombosis, and the patients should be exhaustively informed about the risks associated with therapy. Raloxifene does not show to affect memory and cognition. Finally, it is noteworthy that quality-of-life studies demonstrated some favorable effects of raloxifene. Target Audience: Obstetricians and gynecologists, family physicians Learning Objectives: After completing this CME activity, physicians should be better able to identify the mechanism of action of raloxifene, treat the adverse effects of raloxifene, prescribe raloxifene for patients with osteoporosis, to prevent estrogen receptor–positive breast cancer, as effective therapy in women with osteoporosis and concomitant increased levels of plasma cholesterol, and select the appropriate patients for raloxifene treatment using the patient’s medical history and risk of thromboembolism....
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Keywords {🔍}
raloxifene, journal, effects, estrogen, cancer, issue, treatment, breast, patients, access, subscribe, alerts, articles, authors, abstract, cme, mechanism, action, women, tissue, osteoporosis, therapy, log, register, issues, update, clinical, adverse, buy, prevention, risk, demonstrated, bone, molecular, research, systemic, metabolism, coagulation, pattern, onset, receptorpositive, effective, increased, levels, plasma, cholesterol, physicians, text, subscribers, request,
Topics {✒️}
breast cancer onset endometrial cancer onset journal authors submit full text access positive/adverse effects electronic databases medline life studies demonstrated artificial intelligence training tito silvio md‡ stefania di md demonstrated beneficial effects long-term treatment concomitant increased levels service request 800-638-3030 etoc alerts raloxifene treatment shifts register subscribe individual subscribers log journal tables estrogen agonist cme activity issue clinical efficacy increased levels website subscribe salvatore md carlo md roberto md‡§ giampiero md¶ antonio md anna md marco md emanuele md donato md∥ journal adverse effects center submit tissue type systemic effects favorable effects raloxifene treatment contraindications gizzo osteoporotic fractures literature research cochrane library interval time lipid metabolism coagulation pattern menopausal symptoms antagonist depending
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