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Title[redir]:
Current Opinion in Hematology
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ere. Recent findings In addition to a role in bypassing senescence and the orchestration of the symmetry of hematopoietic stem cell divisions, it has recently become clear that BMI1 also functions in the protection against oxidative stress. In the absence of BMI1, reactive oxygen species accumulate, associating with activation of DNA damage response pathways and increased apoptosis. BMI1-mediated control over reactive oxygen species levels might occur independently of the INK4a/ARF pathway, but rather involves impaired mitochondrial functions. In human hematopoietic malignancies, BMI1 is frequently overexpressed, which associates with poor prognosis. Downmodulation of BMI1 impairs self-renewal and long-term expansion of leukemic stem cells. Summary Understanding molecular mechanisms by which BMI1 affects stem cell fate will increase our insights into the biology of hematopoietic stem cells and will also aid in understanding the process of leukemic transformation and ultimately in the identification of drugable targets that might facilitate the eradication of leukemic stem cells....
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Keywords {🔍}
journal, bmi, stem, leukemic, cells, issue, hematopoietic, access, subscribe, alerts, authors, abstract, normal, current, log, register, logo, articles, issues, role, polycomb, group, gene, buy, molecular, mechanisms, cell, functions, reactive, oxygen, species, understanding, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous, hematopoiesis, edited, hal, broxmeyer,
Topics {✒️}
journal authors submit underlying molecular mechanisms full text access hematopoietic stem cells leukemic hematopoietic stem human hematopoietic malignancies leukemic stem cells ink4a/arf pathway long-term expansion artificial intelligence training bmi1-mediated control etoc alerts service request 800-638-3030 register subscribe individual subscribers log journal tables current knowledge issue abstract hematopoiesis website subscribe bmi1 signaling bmi1 impairs journal leukemic transformation center submit recent findings bypassing senescence oxidative stress increased apoptosis occur independently frequently overexpressed poor prognosis drugable targets email inbox rights reserved data mining broxmeyer role authors content bmi1 functions understanding log subscribers text role edited hal normal jan
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