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Title[redir]:
Journal of Cardiovascular Pharmacology
Description:
TBARS) were measured. In a prospective, open, and end-point-blinded study, 232 patients with an acute myocardial infarction (AMI) were randomized to receive either carvedilol or atenolol at equipotent doses, and the previously mentioned 3 parameters were measured at baseline and after 12 months of active treatment, with changes during the study period being compared both within and between the groups. Ox-LDL decreased in both treatment modalities, from 40.5 ± 15.6 to 35.0 ± 13.8 U/L, P = 0.0001, in the carvedilol group and from 40.3 ± 16.5 to 37.4 ± 13.1 U/L, P = 0.044, in the atenolol group, with a significant between-group difference in the changes (P = 0.036). The levels of vitamin E did not change during carvedilol treatment (31.0 ± 10.2 vs 31.7 ± 11.1 μmol/L), but it decreased marginally in the atenolol group (30.8 ± 12.1 vs 27.2 ± 9.1 μmol/L, P = 0.056), with a significant between-group difference (P = 0.008). No significant change in TBARS was observed between the carvedilol and atenolol groups (P = 0.454). These results indicate that carvedilol has a more pronounced antioxidative effect than atenolol in post-AMI patients, which might be of clinical importance....
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Keywords {🔍}
patients, carvedilol, atenolol, study, treatment, vitamin, oxldl, levels, tbars, groups, group, difference, effects, baseline, receptor, months, antioxidative, ami, significant, betaadrenergic, journal, oxidative, blood, stress, oxidized, cad, shown, receiving, phd, lowdensity, measured, acute, betweengroup, observed, results, effect, coronary, studies, table, plasma, heart, found, lipoprotein, cholesterol, compared, data, peroxidation, serum, samples, blockers,
Topics {✒️}
beta-1-selective-adrenergic receptor blocker oxidized low-density lipoproteins beta-adrenergic receptor blockers high-performance liquid chromatography endothelium-derived relaxing factor gated blood-pool scintigraphy enzyme-linked immunosorbent assay study-suggesting equipotent doses long-term treatment acute myocardial infarction end-point-blinded study ethylenediamine tetraacetic acid journal authors submit angiotensin-converting enzyme selective antioxidant effect oxidative stress markers randomized-controlled comparison coronary artery disease free oxygen radicals potent proatherosclerotic mediator acute coronary syndromes chest pain consistent ice-cold water direct sandwich technique separate antigenic determinants endothelium-dependent relaxation received considerable attention inestimable technical assistance ann intern med artificial intelligence training percutaneous coronary intervention coronary artery stenoses early oral treatment recommending antioxidant supplementation coronary heart disease developing angina pectoris congestive heart failure stronger antioxidant effect native unmodified ldl unique antioxidative effect beneficial antioxidative effect evaluating oxidative stress end-point-blinded cardiovascular risk factors mann-whitney test age-matched controls demonstrated marked increases case-control studies reduce blood pressure nonsteroidal antiinflammatory drugs
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