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Title[redir]:
Cardiology in Review
Description:
been developed that enhance or suppress the likelihood of rupture postmyocardial infarction. The purpose of this review is to describe these recent advances, recognizing that nearly all of the information has been obtained from mouse models of free wall rupture. Although it is probable that the same genetic determinants apply to septal and papillary muscle rupture, the possibility remains that there are unique modulators of risk for rupture at differing anatomic sites within the heart. It is likely that the candidate genes also influence rupture in humans, although this conclusion must be confirmed. The mouse models will be helpful to direct future proteomic and genomic studies in patients and may already suggest certain fundamental pathways. For example, the essential role of collagen production and stabilization postmyocardial infarction may direct therapies to enhance collagen cross-linking and limit its degradation as a strategy to reduce rates of rupture and enhance myocardial healing....
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Keywords {🔍}
rupture, journal, issue, infarction, models, access, subscribe, alerts, authors, abstract, review, myocardial, genetic, enhance, log, register, articles, issues, article, cardiac, information, buy, patients, postmyocardial, mouse, direct, collagen, text, subscribers, request, browse, content, submit, service, privacy, policy, logo, advanced, search, collections, info, previous, insights, murine, sane, david, mozingo, willis, scott, becker,
Topics {✒️}
enhance collagen cross-linking journal authors submit full text access differing anatomic sites artificial intelligence training free wall rupture papillary muscle rupture direct future proteomic stabilization postmyocardial infarction rupture postmyocardial infarction genetic determinants apply enhance myocardial healing willis scott md etoc alerts service request 800-638-3030 register subscribe individual subscribers log journal tables issue collagen production website subscribe myocardial infarction journal influence rupture direct therapies center submit 17 genetic models mouse models uncommon event devastating consequences clinical features molecular influences recent advances possibility remains unique modulators candidate genes genomic studies fundamental pathways essential role reduce rates email inbox rights reserved data mining authors article content rupture enhance information review 17
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