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Title[redir]:
American Journal of Clinical Oncology
Description:
to neoadjuvant therapy may serve as a surrogate marker for treatment efficacy and remains an active area of investigation. Objectives: The chemoradiosensitivity of pancreatic adenocarcinoma has not yet fully been assessed. The purpose of this study is to determine the efficacy of preoperative chemoradiation, measured by the impact on the R0 resection rate and the histopathological response rate in patients presenting with resectable pancreatic adenocarcinoma. Methods: Patients with localized, potentially resectable pancreatic adenocarcinoma were treated with 50 Gy irradiation combined with 5-fluorouracil by continuous infusion (300 mg Β· mβ2 Β· dβ1; day 1β5; week 1β5) and cisplatin (20 mg Β· mβ2 Β· dβ1; day 1β5 and day 29β33). Patients presenting with resectable disease at restaging, without metastatic dissemination, underwent surgical resection. Results: Forty-one patients were enrolled. Twenty-seven patients (67.5%) completed chemoradiation receiving at least 75% prescribed chemotherapy dose without grade 4 nonhematological toxicity. Twenty-six patients (63%) underwent surgical resection with curative intent and 21 (80.7%) had R0 resection. Thirteen of 26 specimens (50%) presented a major pathologic response with more than 80% of severely degenerative cancer cells. Complete pathologic response was observed in one specimen. Median survival time and 2-year survival rate were 9.4 months and 20% for the entire cohort. The local recurrence and 2-year survival rates were 4% and 32%, respectively, for the 26 operated patients. Conclusions: This study suggests that some pancreatic adenocarcinomas are chemoradiosensitive and that preoperative chemoradiation provides antitumoral effect associated with major histopathological response in 50% of patients and a high R0 resection rate. Further research is needed to determine the biologic difference between responders and nonresponders, to evaluate the predictive value of treatment response parameters, and to optimize the chemoradiation regimen....
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Keywords {π}
journal, patients, response, chemoradiation, pancreatic, phd, resection, histopathological, adenocarcinoma, rate, issue, preoperative, resectable, access, log, subscribe, alerts, authors, abstract, study, major, day, survival, register, logo, articles, issues, article, american, buy, purpose, suggests, chemoradiosensitive, antitumoral, effect, high, treatment, efficacy, determine, presenting, underwent, surgical, pathologic, year, text, subscribers, request, browse, content, submit,
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journal authors submit institutional users access r0 resection rate 2-year survival rate full text access underwent surgical resection histopathological response rate median survival time 2-year survival rates artificial intelligence training major pathologic response complete pathologic response gastrointestinal histopathological response major histopathological response resectable pancreatic adenocarcinoma treatment response parameters etoc alerts pierre-jean md jean-yves md completed chemoradiation receiving service request 800-638-3030 register subscribe individual subscribers log journal tables r0 resection access log issue histopathological response pancreatic adenocarcinoma journal resectable disease website subscribe pancreatic adenocarcinomas center submit romuald md franΓ§oise md christian mdβ marc md pascal md preoperative chemoradiation chemoradiation regimen clinical oncology 31 antitumoral effect neoadjuvant therapy surrogate marker treatment efficacy active area continuous infusion metastatic dissemination curative intent
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