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We began analyzing https://www.molbiolcell.org/doi/10.1091/mbc.e05-08-0726, but it redirected us to https://www.molbiolcell.org/doi/10.1091/mbc.e05-08-0726. The analysis below is for the second page.

Title[redir]:
Splicing Speckles Are Not Reservoirs of RNA Polymerase II, but Contain an Inactive Form, Phosphorylated on Serine2 Residues of the C-Terminal Domain | Molecular Biology of the Cell
Description:
“Splicing speckles” are major nuclear domains rich in components of the splicing machinery and polyA+ RNA. Although speckles contain little detectable transcriptional activity, they are found preferentially associated with specific mRNA-coding genes and gene-rich R bands, and they accumulate some unspliced pre-mRNAs. RNA polymerase II transcribes mRNAs and is required for splicing, with some reports suggesting that the inactive complexes are stored in splicing speckles. Using ultrathin cryosections to improve optical resolution and preserve nuclear structure, we find that all forms of polymerase II are present, but not enriched, within speckles. Inhibition of polymerase activity shows that speckles do not act as major storage sites for inactive polymerase II complexes but that they contain a stable pool of polymerase II phosphorylated on serine2 residues of the C-terminal domain, which is transcriptionally inactive and may have roles in spliceosome assembly or posttranscriptional splicing of pre-mRNAs. Paraspeckle domains lie adjacent to speckles, but little is known about their protein content or putative roles in the expression of the speckle-associated genes. We find that paraspeckles are transcriptionally inactive but contain polymerase II, which remains stably associated upon transcriptional inhibition, when paraspeckles reorganize around nucleoli in the form of caps.

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Custom-built

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Traffic Estimate {📈}

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🚄 Respectable Traffic: 10k - 20k visitors per month


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The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

pol, speckles, splicing, rna, figure, google, scholar, cell, medline, crossref, serp, antibodies, nuclear, polymerase, transcription, cells, nucleoplasm, paraspeckles, forms, phosphorylated, total, domains, detected, biol, polya, complexes, sites, αamanitin, levels, iia, transcriptional, found, relative, inhibition, speckle, ser, brrna, pbs, present, nucleus, pombo, ctd, inactive, protein, factors, min, genes, cryosections, small, hela,

Topics {✒️}

injected β-globin pre-mrna 6-dichloro-1-β-d-ribofuranosylbenzimidazole [drb] 6-dichloro-1-β-d-ribofuranosylbenzimidazole unusual c-terminal domain heat shock-induced alterations tak/p-tefb localize cotranscriptional pre-mrna splicing pre-mrna splicing factors chi-square statistical test α-amanitin–treated samples relative depc-phosphate-buffered saline specific mrna-coding genes alexafluor488 goat anti-rabbit extra-nucleolar synthetic sites newly made br-rna bromo-utp–labeled rna phospho-ser5 pol ii tris-buffered saline/tween 20 newly labeled br-rna c-terminal domain alexafluor488 rabbit anti-fitc phospho-ser2 pol ii 100 μg/ml α-amanitin 10 μg/ml α-amanitin anti-pol ii antibodies muscle-specific genes relative google scholar carmo-fonseca specific pre-mrnas found pre-mrna splicing gene-rich r-bands α-amanitin–treated cells white dotted lines phosphate-buffered saline mrna processing factors newly made rna large transcription/splicing complexes hrp-conjugated secondary antibodies rna polymerase ii higher magnification view polymerase ii phosphorylated primary antibodies anti-psp1 multiple heptad repeats cell extract preparation bovine serum albumin contained pol ii western blotting protocols rabbit anti-alexafluor488 slower migrating molecules hyperphosphorylated polymerase ii pol ii studied

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