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Title[redir]:
A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth. | Molecular Biology of the Cell
Description:
A glutathione reductase null mutant of Saccharomyces cerevisiae was isolated in a synthetic lethal genetic screen for mutations which confer a requirement for thioredoxin. Yeast mutants that lack glutathione reductase (glr1 delta) accumulate high levels of oxidized glutathione and have a twofold increase in total glutathione. The disulfide form of glutathione increases 200-fold and represents 63% of the total glutathione in a glr1 delta mutant compared with only 6% in wild type. High levels of oxidized glutathione are also observed in a trx1 delta, trx2 delta double mutant (22% of total), in a glr1 delta, trx1 delta double mutant (71% of total), and in a glr1 delta, trx2 delta double mutant (69% of total). Despite the exceptionally high ratio of oxidized/reduced glutathione, the glr1 delta mutant grows with a normal cell cycle. However, either one of the two thioredoxins is essential for growth. Cells lacking both thioredoxins and glutathione reductase are not viable under aerobic conditions and grow poorly anaerobically. In addition, the glr1 delta mutant shows increased sensitivity to the thiol oxidant diamide. The sensitivity to diamide was suppressed by deletion of the TRX2 gene. The genetic analysis of thioredoxin and glutathione reductase in yeast runs counter to previous studies in Escherichia coli and for the first time links thioredoxin with the redox state of glutathione in vivo.
Title[redir]:
A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth. | Molecular Biology of the Cell
Description:
A glutathione reductase null mutant of Saccharomyces cerevisiae was isolated in a synthetic lethal genetic screen for mutations which confer a requirement for thioredoxin. Yeast mutants that lack glutathione reductase (glr1 delta) accumulate high levels of oxidized glutathione and have a twofold increase in total glutathione. The disulfide form of glutathione increases 200-fold and represents 63% of the total glutathione in a glr1 delta mutant compared with only 6% in wild type. High levels of oxidized glutathione are also observed in a trx1 delta, trx2 delta double mutant (22% of total), in a glr1 delta, trx1 delta double mutant (71% of total), and in a glr1 delta, trx2 delta double mutant (69% of total). Despite the exceptionally high ratio of oxidized/reduced glutathione, the glr1 delta mutant grows with a normal cell cycle. However, either one of the two thioredoxins is essential for growth. Cells lacking both thioredoxins and glutathione reductase are not viable under aerobic conditions and grow poorly anaerobically. In addition, the glr1 delta mutant shows increased sensitivity to the thiol oxidant diamide. The sensitivity to diamide was suppressed by deletion of the TRX2 gene. The genetic analysis of thioredoxin and glutathione reductase in yeast runs counter to previous studies in Escherichia coli and for the first time links thioredoxin with the redox state of glutathione in vivo.
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Keywords {🔍}
glutathione, delta, mutant, glr, biology, reductase, total, trx, cell, high, thioredoxin, ascb, yeast, levels, oxidized, double, american, society, mboc, resources, submit, molecular, article, growth, published, view, pdf, genetic, thioredoxins, sensitivity, diamide, links, downloads, citations, information, search, sign, register, skip, main, navigation, home, current, issue, archive, press, features, collections, recommend, cellvol,
Topics {✒️}
ascb privacy policy glutathione reductase mutant accumulate high levels exceptionally high ratio grow poorly anaerobically yeast runs counter authors subscription rates cell biology powered normal cell cycle glutathione increases 200-fold lack glutathione reductase muller published online thiol oxidant diamide time links thioredoxin oxidized/reduced glutathione glr1 delta trx1 delta high levels cell biology trx2 gene ascb contact glutathione reductase yeast mutants genetic analysis mboc oxidized glutathione search sign 13 oct 2017https saccharomyces cerevisiae twofold increase disulfide form wild type cells lacking aerobic conditions previous studies escherichia coli redox state american society suite 750 rockville usa phone atypon® literatum total glutathione requires thioredoxin sensitivity view cell 50 citations glutathione diamide published
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