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Title[redir]:
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1 | Journal of Experimental Medicine | Rockefeller University Press
Description:
Transcriptional activator Oct2 and cofactor OBF-1 regulate B cell IL-6 to induce T cell production of IL-21, to support Tfh cell development in antiviral i
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Keywords {š}
cells, tfh, cell, mice, google, scholarcrossref, pubmed, response, expression, infection, obf, oct, follicular, formation, fig, development, helper, immunol, bcl, differentiation, loss, gcs, early, responses, vivo, corcoran, activated, immunity, immune, germinal, generation, data, antibody, viral, nurieva, obfdeficient, production, role, day, dko, critical, influenza, gene, center, lns, draining, studies, impaired, sites, httpsdoiorgjimmuni,
Topics {āļø}
chromatin immunoprecipitation il21 messenger rna real-time quantitative pcr α-cd3/α-cd28āstimulated naive cd4+ lung-draining mediastinal lns quantitative rt-pcr α-cd62lācoupled magnetic beads b-cell-specific coactivator obf-1/oca mhc-related immunodominance hierarchies α-cd19ācoupled magnetic beads 350-bp-long pcr products b-cell-specific coactivator oca 10 ng/ml gm-csf attributionānoncommercialāshare alike attributionānoncommercialāshare alike 3 real-time qpcr analysis persistent b-lymphotropic gammaherpesvirus mature effector klrg1+cd44+cd8+ germinal centerāderived memory draining ln cfx384 real-time system sequence-specific dna binding quantitect primer assay ifn-gamma promotes il-6 c-terminal protein domain 10 µg/ml α-cd3 goat α-actin antiserum proteinādna immune complexes germinal center pathway germinal center responses antibody-secreting cell differentiation antibody-secreting plasma cell early b-cell development putative octamer-binding sites tcr-αādeficient mice α-fitc multisort kit slam/sap family receptors octādna complex putative oct2-binding sites total rna specific pathogenāfree facilities cell-specific coactivator obf-1 octamer-binding transcription factors il-21āgfp reporter system cellādependent antibody responses influenza-infected obf-1ādeficient mice share signaling pathways directly contact dna interleukin-6/stat3 signaling regulates detergent-disrupted influenza hkx31
Questions {ā}
- Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
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