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Title[redir]:
Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma: Leukemia & Lymphoma: Vol 50 , No 5 - Get Access
Description:
Glucocorticoids are highly effective chemotherapeutic agents used in the treatment of hematological malignancies, including multiple myeloma (MM). Although a number of new agents have recently been...
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Keywords {π}
hematology, zhejiang, access, journals, sciences, province, peoples, republic, china, open, taylor, francis, search, article, medicine, online, browse, journal, studies, log, articles, key, laboratory, find, environment, science, health, issue, department, affiliated, hospital, institute, university, school, diagnose, treatment, group, page, publish, social, cart, read, glucocorticoid, receptor, pdf, technology, information, register, expression, multiple,
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social care medicine jia-kun shen department hua-ping du department qiu-ling ma department combined multi-organ transplantation downloaded article pdf twitter page taylor research interleukin-6-independent expression article /doi/full/10 francis group journal search calls cart search downloaded article pdfs limited period find guidance jian huang department journals books receive personalised research crossref citations access rights institution access read lists articles published online malignant plasma cells growth inhibitory effect important growth factors applicable share back journals browse citing articles based glucocorticoid receptor expression public health phosphorylated glucocorticoid receptor open drug resistance information multiple myeloma journals a issue table date register article https glucocorticoid receptor issues volume 50 register log crossref icon constitutive expression dexamethasone-sensitive taylor publish search article
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articleSection:Original Article: Research
name:Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma
headline:Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma
abstract:Glucocorticoids are widely used chemotherapeutic agents for multiple myeloma. Drug resistance to steroid therapies is associated with the downregulation or loss of glucocorticoid receptor expression in malignant plasma cells. In this study, we examined the constitutive expression of glucocorticoid receptor in dexamethasone-sensitive and dexamethasone-resistant multiple myeloma cell lines. We found that triptolide increased the amount of the phosphorylated glucocorticoid receptor and enhanced the growth inhibitory effect of dexamethasone. Notably, these effects could not be blocked by interleukin-6, one of the most important growth factors in multiple myeloma.
description:Glucocorticoids are widely used chemotherapeutic agents for multiple myeloma. Drug resistance to steroid therapies is associated with the downregulation or loss of glucocorticoid receptor expression in malignant plasma cells. In this study, we examined the constitutive expression of glucocorticoid receptor in dexamethasone-sensitive and dexamethasone-resistant multiple myeloma cell lines. We found that triptolide increased the amount of the phosphorylated glucocorticoid receptor and enhanced the growth inhibitory effect of dexamethasone. Notably, these effects could not be blocked by interleukin-6, one of the most important growth factors in multiple myeloma.
author:
type:Person
name:Jie Jin
type:Person
name:Hua-Ping Du
type:Person
name:Min Yang
type:Person
name:Jia-Kun Shen
type:Person
name:Jie Jin
type:Person
name:Qiu-Ling Ma
type:Person
name:Jian Huang
keywords:Triptolide, glucocorticoid receptor, MM.1R and MM.1S cell lines, drug resistance
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datePublished:2009-07-21
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