
DOI . ORG {
}
Title[redir]:
Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features | PNAS
Description:
Within the tumor microenvironment, cancer cells coexist with noncancerous adjacent cells that constitute the tumor microenvironment and impact tumor growth through diverse mechanisms. In particular...
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Keywords {๐}
cafs, cancer, cells, tumor, nfs, cell, crossref, pubmed, google, scholar, fig, fibroblasts, caf, genes, expression, immortalized, migration, analysis, lung, patient, appendix, pdependent, mmp, calu, research, cancerassociated, growth, relative, view, microenvironment, control, matrix, israel, movie, features, proteins, promote, invasion, articles, nat, article, nonautonomous, adjacent, secreted, gene, experiments, science, download, author, biology,
Topics {โ๏ธ}
cell-autonomous tumor-suppressive features supporting information appendix prognostic gene-expression signature jan-willem van ittersum ฮฑ-smooth muscle actin cancer-supporting features proceedings mcherry-labeled h460 cells counterparts display neoplastic-specific growth-factor-driven resistance p53-mediated tumour suppression nonautonomous tumor-suppressive functions cancer-relevant surface receptors gfp-expressing immortalized nfshp53 orchestrate tumor-promoting inflammation mcherry-expressing h460 cells margarete fischer-bosch institute mcherry-expressing calu1 cells p53-dependent transcription program prognostic significance nf-kappab-dependent manner social media facebook partially p53-dependent manner cell-autonomous tumor suppression early-onset lung cancer cancer-supporting features gfp-expressing immortalized cafshp53 numerous caf-specific genes p53-dependent transcriptome partially p53-dependent transcriptional program tp53 coding-region mutations distinctive cancer-promoting features van der kuip spin-ordered expression matrix pnas direct submission current emotional state wild-type p53 activity national academy cancer development gfp-expressing immortalized fibroblasts gfp-expressing immortalized cafshlacz sophisticated auditoryโmotor learning citation information supporting tumor progression gfp-expressing control nfs liquid chromatography-ms p53 wild-type conformation authors declare adeno-squamous carcinoma lung cancer-derived cafs cell nonautonomous manner
Questions {โ}
- Y Aylon, M Oren, The paradox of p53: What, how, and why?
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