
DOI . ORG {
}
Title[redir]:
Tumor-specific IL-9–producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers | PNAS
Description:
Because cytokine-priming signals direct CD8+ T cells to acquire unique profiles that affect their ability to mediate specific immune responses, here we generated IL-9–skewed CD8+ T (Tc9) cells by p...
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Keywords {🔍}
cells, transfer, tumor, mice, fig, transferred, pubmed, crossref, google, scholar, adoptive, effector, antitumor, ifnγ, cancer, vivo, expression, cytolytic, production, tcell, research, responses, immunotherapy, results, cell, established, cytokine, cleveland, large, persistence, melanoma, immunol, adoptively, oti, spleens, compared, tclike, shown, view, ability, tumorbearing, appendix, clinic, article, ilproducing, superior, cytotoxic, differentiation, number, articles,
Topics {✒️}
long-lasting ifn-γ–producing tc1 treated b16-ova–bearing cd45 supporting information appendix il-6-stat3 signaling pathway il-9–producing tc9-cell phenotype jan-willem van ittersum social media facebook display full-mature phenotype grzb-positive tc9-derived cells optimal t-cell subsets specific pathogen-free conditions 1+cd8+ t-cell infiltration cd8+ t-cell subsets long-term lived cells th9-polarizing conditions induced tumor-specific tc17 effector mc38-gp100 tumor model grzb-producing tumor-infiltrating short-lived effector cd8 cd8+ t-cell subset tumor antigen-specific cd8+ t-bet transcription factor pmel-1/b16 melanoma models tumor-specific tc9 cells pmel-1/b16 mouse models acquire/maintain effector function th9 cell-derived il-9 ifn-gamma-facilitated rejection tumor-reactive tc9 cells anti–ifn-γ antibodies ifn-γ–positive tc1 tc9 cell-treated mice tumor-specific tc1 cells tc9-derived ifn-γ tc9-cell transfer mediated ifn-γ–producing tc1 ifn-γ–producing tc1 augment antigen-drive acquisition treated tumor-bearing mice sustained antitumor response real-time pcr analysis ifn-γ–neutralizing antibodies tc1 cell-treated mice national academy t-cell transfer immunotherapy t-cell adoptive transfer generated il-9–skewed cd8+ pmel-1–derived tc9 cells tc9 cell-transferred mice received t-cell transfer
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