
DOI . ORG {
}
Title[redir]:
A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation | PNAS
Description:
The detection of ligand-binding sites is often the starting point for protein function identification and drug discovery. Because of inaccuracies in predicted protein structures, extant binding poc...
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Keywords {🔍}
binding, protein, findsite, google, scholar, templates, crossref, proteins, pubmed, prediction, target, site, structures, ligand, predicted, structure, threading, ligandbinding, models, identified, sites, function, accuracy, sequence, crystal, ligsitecsc, residues, template, pockets, center, pocket, dataset, results, selected, fig, ligands, molecular, share, methods, top, identity, pdf, information, distance, number, prospector, topranked, download, article, functional,
Topics {✒️}
org/cgi/content/full/0707684105/dc1 jan-willem van ittersum social media facebook ligand-based virtual screening motif-based searches frequently ligand-binding/interaction motif ma marti-renom ligand-binding signatures detected ligand-binding motif prediction ligand-binding site identification supporting information online ligand-binding site prediction structure-based drug design identified genes/gene products identify ligand-binding sites binding-site prediction procedure template–consensus-binding residues template–consensus-binding pockets structure-based function identification structure-based drug discovery identified ligand-binding sites predicted ligand-binding sites top-ranked binding pocket sophisticated auditory–motor learning lower-quality predicted models identified ligand-bound templates ligand-bound crystal structures pnas direct submission protein–ligand crystal complex supporting information top-ranked prospector_3 template consensus-binding site putative binding site top-ranked threading templates top-ranked prospector_3 templates findsite threading-based approaches librarian recommend pnas binding-site prediction ligand-binding site authors declare pnas highlights newsletter binding-site detection national academy current emotional state ligand-bound forms ligand-binding regions binding-site similarity common binding site evolutionary related homologues modified amino acids
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