DOI . ORG {
}
We began analyzing https://www.pnas.org/doi/full/10.1073/pnas.0404781101, but it redirected us to https://www.pnas.org/doi/full/10.1073/pnas.0404781101. The analysis below is for the second page.
Title[redir]:
Discovery of an allosteric site in the caspases | PNAS
Description:
Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and liga...
Title[redir]:
Discovery of an allosteric site in the caspases | PNAS
Description:
Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and liga...
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Keywords {🔍}
caspase, dica, pubmed, crossref, google, scholar, fica, site, active, missing, invalidmedia, allosteric, cavity, caspases, fig, binding, central, small, compounds, chain, data, zymogen, substratebinding, discovery, sites, cysteine, loops, modification, bound, subunit, pdb, chem, tethering, structures, large, inhibitors, code, article, pnas, research, access, information, view, dimer, drug, cell, region, modified, fragments, protein,
Topics {✒️}
04 mm carbobenzyloxy-asp-glu-val-asp 5-fluoro-1h-indole-2-carboxylic acid asp-glu-val-asp authors affiliations jeanne discussion active caspases-3 pcr-amplified coding sequence supporting information applied biosystems/mds sciex jan-willem van ittersum ac-devd-aminof luorocoumarin xiap-bir3-inhibited caspase-9 scored thiol-free analogs lost hanging-drop vapor diffusion catalytic cysteine-histidine dyads 34 abstract materials small-subunit-coding sequence x-ray crystal structures reversible thiol–disulfide interchange sophisticated auditory–motor learning caspase-9/xiap-bir3 domain author notes ‡ current emotional state liquid chromatography/mass spectrometry caspase-7/fica space group substrate-binding region loops procaspase-7 expression plasmid caspase-3-dependent apoptosis assay caspase substrate-binding region citation information librarian recommend pnas caspase substrate-binding regions notes abbreviations direct molecular replacement national academy wild-type caspase-7 bound share pnas web site generous prepublication access allosteric peptide inhibitors active-site-directed compounds allosterically inhibited caspase-7/dica peptide substrate mimic download pdf nguyen† sunesis pharmaceuticals pnas highlights newsletter study allosteric transitions oligonucleotide-directed mutagenesis caspase-based therapeutics identical substrate preference kd values ranging
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