
DOI . ORG {
}
Title[redir]:
Brk is coamplified with ErbB2 to promote proliferation in breast cancer | PNAS
Description:
Amplification of the receptor tyrosine kinase ErbB2 is frequently observed in breast cancer. Amplification of erbB2 is also associated with multiple genomic gains and losses; however, the importanc...
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Keywords {🔍}
brk, erbb, cells, breast, cell, proliferation, cancer, kinase, scholar, crossref, pubmed, google, expression, activation, fig, tumors, mammary, erbbinduced, activity, signaling, tyrosine, pathway, epithelial, cold, spring, harbor, cyclin, levels, coexpression, mcfa, min, view, human, tumor, observed, overexpression, lapatinib, determine, acbbrk, cycle, mice, articles, article, information, growth, expressing, increase, data, generated, analysis,
Topics {✒️}
org/cgi/content/full/0805009105/dcsupplemental mcf-10a-based cell lines serum-free dmem/f12 medium social media facebook anne-lise borresen-dale jan-willem van ittersum median-polished log ratios clinically relevant link ligand-independent receptor homodimerization anti-rabbit antibody conjugated supporting information online increases anchorage-independent growth parental erbb2-expressing cells receptor protein-tyrosine kinase heregulin-induced cell proliferation β-actin immunoblot serves anti-fade prolong reagent inhibit erbb-induced proliferation cold spring harbor regulates heregulin-induced activation inhibit erbb2-induced proliferation erbb2-induced cell proliferation wild-type erbb2 receptors horizontal dotted lines anti-erbb2 therapeutic strategies alexa fluor dyes promote egf-independent proliferation sophisticated auditory–motor learning supporting information induce egf-independent proliferation erbb2-postive breast cancer immortalized egf-dependent erbb2-brk signaling axis full-length erbb2 brk-transplanted mice started growth factor-starved cells erbb2-induced maximal activation cleared fat pads authors declare tumor cell–specific function solid straight line promotes cell proliferation mammary epithelial cells promote erbb2-induced activation c-terminal tyrosine 447 murine mammary tumorigenesis epidermal growth factor enhances downstream signaling librarian recommend pnas p38 map kinases
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