Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://www.nature.com/articles/srep35215, but it redirected us to https://www.nature.com/articles/srep35215. The analysis below is for the second page.

Title[redir]:
A Renal Olfactory Receptor Aids in Kidney Glucose Handling | Scientific Reports
Description:
Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels. Consistent with this phenotype, Olfr1393 knockout mice have a significant decrease in luminal expression of Sglt1, a key renal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1. In addition, by utilizing a large scale screen of over 1400 chemicals we reveal the ligand profile of Olfr1393 for the first time, offering new insight into potential pathways of physiological regulation for this novel signaling pathway.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We don’t know how the website earns money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

olfr, sglt, glucose, mice, pubmed, cells, scholar, google, cas, kidney, tubule, expression, renal, proximal, fig, blood, olfactory, cell, ligands, receptors, physiol, ors, regulation, found, rtpcr, total, males, females, central, receptor, apical, nature, odorant, performed, measured, role, mouse, membrane, supplemental, antibody, data, glycosuria, differences, insulin, tissues, previously, localization, segments, detected, kidneys,

Topics {✒️}

nature portfolio privacy policy author information authors policies advertising nature 442 nature na+-d-glucose cotransporter sglt2 na+-d-glucose cotransporter sglt1 0/ reprints modulating dynamin-dependent release gas chromatography-mass spectrometry structure-based drug design nih grants r00-dk081610 julius-von-sachs-institute julius-von-sachs-platz 2 amp-activated protein kinase hrp-conjugated secondary antibodies standard phenol-chloroform protocol flag-conjugated agarose beads dual-luciferase reporter assay free access na+/glucose cotransporter expression glucose/galactose malabsorption due evaluating cell-surface expression d-glucose cotransporter sglt1 protein-coupled odorant receptors cleavable lucy tag glucose-dependent incretin secretion full size image sglt-mediated glucose reabsorption account age-related decline middle overexpressing flag-tagged olfr1393 lucy-flag-olfr1393 construct widespread ectopic expression chemical library permissions ltl + tubule expressing sglt na-k-atpase activity neomycin selection marker sensory signaling systems urinary glucose-creatinine levels drug discovery mock rt-pcr reactions elevated protein/creatinine ratios dmem/f12 media johns hopkins chemcore luminal/total sglt stain fine-tune sglt1 regulation

Questions {❓}

  • How does your kidney smell?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A Renal Olfactory Receptor Aids in Kidney Glucose Handling
         description:Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels. Consistent with this phenotype, Olfr1393 knockout mice have a significant decrease in luminal expression of Sglt1, a key renal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1. In addition, by utilizing a large scale screen of over 1400 chemicals we reveal the ligand profile of Olfr1393 for the first time, offering new insight into potential pathways of physiological regulation for this novel signaling pathway.
         datePublished:2016-10-14T00:00:00Z
         dateModified:2016-10-14T00:00:00Z
         pageStart:1
         pageEnd:13
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/srep35215
         keywords:
            Kidney
            Metabolism
            Olfactory receptors
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig6_HTML.jpg
         isPartOf:
            name:Scientific Reports
            issn:
               2045-2322
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Blythe D. Shepard
               affiliation:
                     name:Johns Hopkins University School of Medicine
                     address:
                        name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lydie Cheval
               affiliation:
                     name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
                     address:
                        name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zita Peterlin
               affiliation:
                     name:Columbia University
                     address:
                        name:Department of Biological Sciences, Columbia University, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stuart Firestein
               affiliation:
                     name:Columbia University
                     address:
                        name:Department of Biological Sciences, Columbia University, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hermann Koepsell
               affiliation:
                     name:Julius-von-Sachs-Institute, University Wurzburg
                     address:
                        name:Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University Wurzburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alain Doucet
               affiliation:
                     name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
                     address:
                        name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jennifer L. Pluznick
               affiliation:
                     name:Johns Hopkins University School of Medicine
                     address:
                        name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A Renal Olfactory Receptor Aids in Kidney Glucose Handling
      description:Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels. Consistent with this phenotype, Olfr1393 knockout mice have a significant decrease in luminal expression of Sglt1, a key renal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1. In addition, by utilizing a large scale screen of over 1400 chemicals we reveal the ligand profile of Olfr1393 for the first time, offering new insight into potential pathways of physiological regulation for this novel signaling pathway.
      datePublished:2016-10-14T00:00:00Z
      dateModified:2016-10-14T00:00:00Z
      pageStart:1
      pageEnd:13
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/srep35215
      keywords:
         Kidney
         Metabolism
         Olfactory receptors
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsrep35215/MediaObjects/41598_2016_Article_BFsrep35215_Fig6_HTML.jpg
      isPartOf:
         name:Scientific Reports
         issn:
            2045-2322
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Blythe D. Shepard
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lydie Cheval
            affiliation:
                  name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
                  address:
                     name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zita Peterlin
            affiliation:
                  name:Columbia University
                  address:
                     name:Department of Biological Sciences, Columbia University, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stuart Firestein
            affiliation:
                  name:Columbia University
                  address:
                     name:Department of Biological Sciences, Columbia University, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hermann Koepsell
            affiliation:
                  name:Julius-von-Sachs-Institute, University Wurzburg
                  address:
                     name:Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University Wurzburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alain Doucet
            affiliation:
                  name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
                  address:
                     name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jennifer L. Pluznick
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Scientific Reports
      issn:
         2045-2322
      volumeNumber:6
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
      name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
      address:
         name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
         type:PostalAddress
      name:Columbia University
      address:
         name:Department of Biological Sciences, Columbia University, New York, USA
         type:PostalAddress
      name:Columbia University
      address:
         name:Department of Biological Sciences, Columbia University, New York, USA
         type:PostalAddress
      name:Julius-von-Sachs-Institute, University Wurzburg
      address:
         name:Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University Wurzburg, Germany
         type:PostalAddress
      name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
      address:
         name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
         type:PostalAddress
      name:Johns Hopkins University School of Medicine
      address:
         name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Blythe D. Shepard
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Lydie Cheval
      affiliation:
            name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
            address:
               name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
               type:PostalAddress
            type:Organization
      name:Zita Peterlin
      affiliation:
            name:Columbia University
            address:
               name:Department of Biological Sciences, Columbia University, New York, USA
               type:PostalAddress
            type:Organization
      name:Stuart Firestein
      affiliation:
            name:Columbia University
            address:
               name:Department of Biological Sciences, Columbia University, New York, USA
               type:PostalAddress
            type:Organization
      name:Hermann Koepsell
      affiliation:
            name:Julius-von-Sachs-Institute, University Wurzburg
            address:
               name:Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University Wurzburg, Germany
               type:PostalAddress
            type:Organization
      name:Alain Doucet
      affiliation:
            name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers
            address:
               name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
               type:PostalAddress
            type:Organization
      name:Jennifer L. Pluznick
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
      name:Department of Biological Sciences, Columbia University, New York, USA
      name:Department of Biological Sciences, Columbia University, New York, USA
      name:Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University Wurzburg, Germany
      name:Sorbonne Universités, UPMC Univ Paris 06, INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, CNRS, ERL 8228, Centre de Recherche des Cordeliers, Paris, France
      name:Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, USA

Social Networks {👍}(2)

External Links {🔗}(380)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.13s.