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We began analyzing https://www.nature.com/articles/1209085, but it redirected us to https://www.nature.com/articles/1209085. The analysis below is for the second page.

Title[redir]:
Perturbations of the AKT signaling pathway in human cancer | Oncogene
Description:
AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse cellular processes including cell proliferation and survival, cell size and response to nutrient availability, tissue invasion and angiogenesis. Many oncoproteins and tumor suppressors implicated in cell signaling/metabolic regulation converge within the AKT signal transduction pathway in an equilibrium that is altered in many human cancers by activating and inactivating mechanisms, respectively, targeting these inter-related proteins. We review a burgeoning literature implicating aberrant AKT signaling in many sporadic human cancers as well as in several dominantly inherited cancer syndromes known as phakomatoses. The latter include disorders caused by germline mutations of certain tumor suppressor genes, that is, PTEN, TSC2/TSC1, LKB1, NF1, and VHL, encoding proteins that intersect with the AKT pathway. We also review various pathogenic mechanisms contributing to activation of the AKT pathway in human malignancy as well as current pharmacologic strategies to target therapeutically components of this pathway.

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Keywords {🔍}

cancer, oncogene, res, testa, nature, cell, sci, altomare, access, rev, cheng, article, bellacosa, natl, usa, akt, proc, acad, pathway, content, signaling, human, wang, tsichlis, cookies, lee, genet, clin, nat, liu, privacy, open, biochem, kim, yang, nicosia, oncol, sun, data, review, kinases, activation, kleinszanto, cristofano, science, thomas, trends, pandolfi, feldman, majumder,

Topics {✒️}

nature portfolio permissions reprints cancer research privacy policy nature advertising tumor suppressor genes akt-mtor signalling axis current pharmacologic strategies social media author information authors akt signaling pathway springerlink instant access author correspondence breast cancer res personal data activated tyrosine kinases data protection permissions article altomare tumor suppressors implicated akt pathway human malignancy epigenetic activation article purchase privacy article cite access human cancer deborah inter-related proteins sporadic human cancers explore content subscription content cancer drug targets cancer antonino glavianoaaron european economic area include disorders caused target therapeutically components institutional subscriptions read muise-helmericks rc nih grants ca77429 targeted therapies accepting optional cookies article journals search log pathogenic mechanisms contributing functional activation cancer met rev manage preferences targeting

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