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We began analyzing https://www.nature.com/articles/1207261, but it redirected us to https://www.nature.com/articles/1207261. The analysis below is for the second page.

Title[redir]:
Myc pathways provoking cell suicide and cancer | Oncogene
Description:
A paradox for the cancer biology field has been the revelation that oncogenes, once thought to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is the quintessential oncogene in this respect, as in normal cells it is required for cell cycle traverse, whereas in cancers it is overexpressed and functions as the angiogenic switch. Nonetheless, Myc overexpression kills normal cells dead in their tracks. Here we review Myc-induced pathways that contribute to the apoptotic response. Molecular analysis of Myc-induced tumors has established that some of these apoptotic pathways are essential checkpoints that guard the cell from cancer, as they are selectively bypassed during tumorigenesis. The precise mechanism(s) by which Myc targets these pathways are largely unresolved, but we propose that they involve crosstalk and feedback regulatory loops between arbiters of cell death.

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Keywords {🔍}

cell, biol, mol, dev, nature, genes, cancer, oncogene, sci, usa, proc, natl, acad, cleveland, science, embo, chem, sherr, eisenman, evan, nat, van, roussel, res, korsmeyer, myc, zambetti, wang, article, access, bishop, levine, yang, lowe, cole, thompson, research, content, nilsson, death, eischen, littlewood, sedivy, differ, biochem, immunol, nevins, eilers, cookies, pathways,

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permissions reprints nature portfolio privacy policy advertising social media ovarian research author information authors research hospital review myc-induced pathways author correspondence research personal data data protection springerlink instant access permissions nature privacy myc-induced tumors explore content subscription content european economic area feedback regulatory loops institutional subscriptions read von der lehr american lebanese syrian bet-directed protacs accepting optional cookies normal cells colon cancer daniel journals search log dei tos ap owen-schaub lb mcdonald 3rd er munoz-alonso mj de alboran im st jude children' el-deiry ws iruela-arispe ml cell death differ da costa lt cancer biology field manage preferences simply provide advantages nucleic acids res van de kamp o'donnell ka van buskirk ha wallace-brodeur rr hamilton sr cell cycle traverse

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      headline:Myc pathways provoking cell suicide and cancer
      description:A paradox for the cancer biology field has been the revelation that oncogenes, once thought to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is the quintessential oncogene in this respect, as in normal cells it is required for cell cycle traverse, whereas in cancers it is overexpressed and functions as the angiogenic switch. Nonetheless, Myc overexpression kills normal cells dead in their tracks. Here we review Myc-induced pathways that contribute to the apoptotic response. Molecular analysis of Myc-induced tumors has established that some of these apoptotic pathways are essential checkpoints that guard the cell from cancer, as they are selectively bypassed during tumorigenesis. The precise mechanism(s) by which Myc targets these pathways are largely unresolved, but we propose that they involve crosstalk and feedback regulatory loops between arbiters of cell death.
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