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We began analyzing https://www.nature.com/articles/nsmb.2345, but it redirected us to https://www.nature.com/articles/nsmb.2345. The analysis below is for the second page.

Title[redir]:
Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation | Nature Structural & Molecular Biology
Description:
RNA 3′-end formation is thought to be crucial in controlling gene expression. Direct RNA sequencing was used to analyze the 3′ ends of Arabidopsis thaliana RNA in unprecedented detail, revealing extreme heterogeneity of RNA 3′ ends, patterns of cleavage and polyadenylation, and previously unrecognized noncoding RNAs. It has recently been shown that RNA 3′-end formation plays a more widespread role in controlling gene expression than previously thought. To examine the impact of regulated 3′-end formation genome-wide, we applied direct RNA sequencing to A. thaliana. Here we show the authentic transcriptome in unprecedented detail and describe the effects of 3′-end formation on genome organization. We reveal extreme heterogeneity in RNA 3′ ends, discover previously unrecognized noncoding RNAs and propose widespread reannotation of the genome. We explain the origin of most poly(A)+ antisense RNAs and identify cis elements that control 3′-end formation in different registers. These findings are essential to understanding what the genome actually encodes, how it is organized and how regulated 3′-end formation affects these processes.

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Keywords {🔍}

article, google, scholar, cas, rna, nature, arabidopsis, polyadenylation, genome, cell, sequencing, reveals, access, plant, end, genes, content, analysis, data, formation, nat, biol, cookies, biology, thaliana, polya, alternative, mol, transcription, sci, usa, mrna, privacy, molecular, direct, simpson, genomewide, polymerase, transcripts, transcriptional, proc, natl, acad, res, human, research, supplementary, processing, information, cleavage,

Topics {✒️}

nature portfolio permissions reprints privacy policy trivalent editing author information authors advertising research genome-wide high-resolution mapping social media nature 227 nature 469 nature 461 nature direct rna sequencing u-rich rna elements european economic area potential secondary structures double-stranded rna degradation pathogen-inducible endogenous sirna dicistronic trna-snorna precursor chimeric gene-transposon transcripts high-resolution transcriptional landscape springerlink instant access institutional subscriptions read permissions identify cis elements rna-seq experiments direct sequencing natural antisense transcripts personal data oncogenic rna viruses endogenous sirnas derived distinct expression patterns data protection drs data helicos biosciences corporation privacy generated rna samples extensive alternative polyadenylation genome-wide scale genome-wide atlas reveal extreme heterogeneity �dark matter” transcripts plant u13 orthologues genome-wide landscape transcriptome microarray experiments explore content subscription content mrna 3′-end formation integrated genome browser

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         description:RNA 3′-end formation is thought to be crucial in controlling gene expression. Direct RNA sequencing was used to analyze the 3′ ends of Arabidopsis thaliana RNA in unprecedented detail, revealing extreme heterogeneity of RNA 3′ ends, patterns of cleavage and polyadenylation, and previously unrecognized noncoding RNAs. It has recently been shown that RNA 3′-end formation plays a more widespread role in controlling gene expression than previously thought. To examine the impact of regulated 3′-end formation genome-wide, we applied direct RNA sequencing to A. thaliana. Here we show the authentic transcriptome in unprecedented detail and describe the effects of 3′-end formation on genome organization. We reveal extreme heterogeneity in RNA 3′ ends, discover previously unrecognized noncoding RNAs and propose widespread reannotation of the genome. We explain the origin of most poly(A)+ antisense RNAs and identify cis elements that control 3′-end formation in different registers. These findings are essential to understanding what the genome actually encodes, how it is organized and how regulated 3′-end formation affects these processes.
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      headline:Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation
      description:RNA 3′-end formation is thought to be crucial in controlling gene expression. Direct RNA sequencing was used to analyze the 3′ ends of Arabidopsis thaliana RNA in unprecedented detail, revealing extreme heterogeneity of RNA 3′ ends, patterns of cleavage and polyadenylation, and previously unrecognized noncoding RNAs. It has recently been shown that RNA 3′-end formation plays a more widespread role in controlling gene expression than previously thought. To examine the impact of regulated 3′-end formation genome-wide, we applied direct RNA sequencing to A. thaliana. Here we show the authentic transcriptome in unprecedented detail and describe the effects of 3′-end formation on genome organization. We reveal extreme heterogeneity in RNA 3′ ends, discover previously unrecognized noncoding RNAs and propose widespread reannotation of the genome. We explain the origin of most poly(A)+ antisense RNAs and identify cis elements that control 3′-end formation in different registers. These findings are essential to understanding what the genome actually encodes, how it is organized and how regulated 3′-end formation affects these processes.
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Social Networks {👍}(1)

External Links {🔗}(232)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
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Mail Servers:

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Name Servers:

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CDN Services {📦}

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