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We began analyzing https://www.nature.com/articles/nrn.2017.15, but it redirected us to https://www.nature.com/articles/nrn.2017.15. The analysis below is for the second page.

Title[redir]:
Integration of optogenetics with complementary methodologies in systems neuroscience | Nature Reviews Neuroscience
Description:
Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kimet al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible. Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell patterning. This outcome has been facilitated not only by the development of core features of optogenetics over the past 10 years (microbial-opsin variants, opsin-targeting strategies and light-targeting devices) but also by the recent integration of optogenetics with complementary technologies, spanning electrophysiology, activity imaging and anatomical methods for structural and molecular analysis. This integrated approach now supports optogenetic identification of the native, necessary and sufficient causal underpinnings of physiology and behaviour on acute or chronic timescales and across cellular, circuit-level or brain-wide spatial scales.

Matching Content Categories {๐Ÿ“š}

  • Education
  • Science
  • Business & Finance

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Custom-built

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Traffic Estimate {๐Ÿ“ˆ}

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๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {๐Ÿ”}

pubmed, article, google, scholar, cas, central, nature, nat, neural, optogenetic, neurons, deisseroth, cell, optogenetics, neurosci, activity, methods, control, imaging, neuron, science, access, optical, circuit, usa, channelrhodopsin, neuroscience, memory, sci, information, opsin, vivo, light, brain, mice, content, opsins, amygdala, proc, natl, acad, stanford, systems, kim, neuronal, variants, zhang, circuits, genetically, activation,

Topics {โœ’๏ธ}

permissions reprints privacy policy nature portfolio journals advertising nature portfolio blue-light-excited gcamp sensors social media red-light-activated excitatory opsin light-gated chloride channel stabilized step-function opsin ฮฒ2-adrenergic receptor signaling blue-light-excited gcamps brain-wide spatial scales cell type-divergent signaling fibre-optic cannula implanted multiple-feature boolean logic light-activated chloride channel blue light-activated channelrhodopsins author correspondence integrating multimodal data temporally precise manner airways-related sensory circuitry systematic input-output mapping efficient retrograde transport recent review covers high-fidelity optical reporting tissueโ€“hydrogel hybrid creation light-driven proton pumps ฮฒ-adrenergic receptor signalling green algae channelrhodopsin entorhinal-hippocampal functional connectivity fiber-optic calcium recording opsin-expressing virus red-shifted optogenetic excitation central noradrenaline circuit theta phase-specific manipulation virtual-navigation decision task channelrhodopsin-2-assisted circuit mapping neocortical excitation/inhibition balance long-range callosal projections tools cell-type-specific expression neuron-type-specific signals control risky decision-making red-shifted variant enhances theta oscillations temporally precise widespread gene transfer gcamp3-facilitated ca2+ imaging personal data

Schema {๐Ÿ—บ๏ธ}

WebPage:
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         headline:Integration of optogenetics with complementary methodologies in systems neuroscience
         description: Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kimet al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible. Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell patterning. This outcome has been facilitated not only by the development of core features of optogenetics over the past 10 years (microbial-opsin variants, opsin-targeting strategies and light-targeting devices) but also by the recent integration of optogenetics with complementary technologies, spanning electrophysiology, activity imaging and anatomical methods for structural and molecular analysis. This integrated approach now supports optogenetic identification of the native, necessary and sufficient causal underpinnings of physiology and behaviour on acute or chronic timescales and across cellular, circuit-level or brain-wide spatial scales.
         datePublished:2017-03-17T00:00:00Z
         dateModified:2017-03-17T00:00:00Z
         pageStart:222
         pageEnd:235
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            Neurophysiology
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            Biological Techniques
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            Animal Genetics and Genomics
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      headline:Integration of optogenetics with complementary methodologies in systems neuroscience
      description: Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kimet al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible. Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell patterning. This outcome has been facilitated not only by the development of core features of optogenetics over the past 10 years (microbial-opsin variants, opsin-targeting strategies and light-targeting devices) but also by the recent integration of optogenetics with complementary technologies, spanning electrophysiology, activity imaging and anatomical methods for structural and molecular analysis. This integrated approach now supports optogenetic identification of the native, necessary and sufficient causal underpinnings of physiology and behaviour on acute or chronic timescales and across cellular, circuit-level or brain-wide spatial scales.
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         Animal Genetics and Genomics
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