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We began analyzing https://www.nature.com/articles/nm.2446, but it redirected us to https://www.nature.com/articles/nm.2446. The analysis below is for the second page.

Title[redir]:
A human memory T cell subset with stem cell–like properties | Nature Medicine
Description:
Whether there exists a human memory T cell population with stem cell–like properties of self-renewal and multipotency is under active investigation. Here Gattinoni et al. characterize a subset of human T cells that phenotypically resemble naive T cells yet have properties associated with memory T cells. These T cells show enhanced ability to self renew and to give rise to differentiated memory cell subsets, suggesting a stem cell–like functionality. Immunological memory is thought to depend on a stem cell–like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells. These cells, specific to multiple viral and self-tumor antigens, were found within a CD45RO−, CCR7+, CD45RA+, CD62L+, CD27+, CD28+ and IL-7Rα+ T cell compartment characteristic of naive T cells. However, they expressed large amounts of CD95, IL-2Rβ, CXCR3, and LFA-1, and showed numerous functional attributes distinctive of memory cells. Compared with known memory populations, these lymphocytes had increased proliferative capacity and more efficiently reconstituted immunodeficient hosts, and they mediated superior antitumor responses in a humanized mouse model. The identification of a human stem cell–like memory T cell population is of direct relevance to the design of vaccines and T cell therapies.

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Custom-built

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🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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Keywords {🔍}

article, google, scholar, cas, memory, cells, cell, nature, human, cancer, med, effector, usa, nat, immunity, stem, gattinoni, access, immunol, national, research, content, restifo, naive, subsets, function, medicine, roederer, differentiation, sci, cookies, lugli, june, antitumor, proc, natl, acad, exp, institutes, health, institute, center, privacy, data, celllike, price, central, open, expression, tcell,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising vaccine research center social media weissman nature intramural research programs gene expression profiling t-bet transcription factor wnt/β-catenin signaling nature 401 nature 396 nature 460 nature flow cytometric data t-cell receptor diversity cancer research graft-versus-host disease long-lived human memory coexpress tumor-specific receptors short-lived effector cd8 cd8+ t-cell memory springerlink instant access tissue-resident memory cd8+ permissions renewing tumor-specific cd8+ research transcription factor eomesodermin personal data data protection adoptively transferred cd8+ human stem cell /tumor-reactive cd8+ peptide vaccine-treated privacy t-cell immunity competing financial interests high car intensity subject protocols content memory central memory cd8+ enrico lugli vivo antitumor efficacy derive central memory cells influence naïve cells marcus buggertdavid human mait cells properties luca gattinoni cell therapy

Questions {❓}

Homeostatic T cell proliferation: how far can T cells be activated to self-ligands?

Schema {🗺️}

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