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We began analyzing https://www.nature.com/articles/39086, but it redirected us to https://www.nature.com/articles/39086. The analysis below is for the second page.

Title[redir]:
Circadian oscillation of a mammalian homologue of the Drosophila period gene | Nature
Description:
Many biochemical, physiological and behavioural processes in organisms ranging from microorganisms to vertebrates exhibit circadian rhythms1. In Drosophila, the gene period (per) is required for the circadian rhythms of locomotor activity and eclosion behaviour2. Oscillation in the levels of per mRNA and Period (dPer) protein in the fly brain is thought to be responsible for the rhythmicity3,4. However, no per homologues in animals other than insects have been identified. Here we identify the human and mouse genes (hPER and mPer, respectively) encoding PAS-domain (PAS, a dimerization domain present in Per, Amt and Sim)-containing polypeptides that are highly homologous to dPer. Besides this structural resemblance, mPer shows autonomous circadian oscillation in its expression in the suprachiasmatic nucleus, which is the primary circadian pacemaker in the mammalian brain5,6. Clock, a mammalian clock gene encoding a PAS-containing polypeptide7,8, has now been cloned: it is likely that the Per homologues dimerize with other molecule(s) such as Clock through PAS–PAS interaction in the circadian clock system.

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article, google, scholar, circadian, cas, nature, clock, drosophila, gene, period, ads, access, science, content, cookies, suprachiasmatic, privacy, mammalian, protein, brain, expression, open, usa, rosbash, research, data, oscillation, tei, okamura, shigeyoshi, mouse, nucleus, behavior, molecular, melanogaster, proc, natl, acad, sci, hall, cloning, functional, young, advertising, information, journal, subscribe, hajime, sakaki, rhythms,

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nature portfolio permissions reprints privacy policy scripps research institute research grants advertising subscribe nature social media nature 343 nature 326 nature 389 nature author information authors 14c-labeled deoxyglucose uptake high-latitude amur minnow author correspondence personal data springerlink instant access data protection permissions development privacy circadian vip rhythm explore content subscription content species-specific behavior clock gene period2 european economic area dimerization domain present primary circadian pacemaker institutional subscriptions read transgenic bac rescue conserved coding dna accepting optional cookies encoding pas-domain drosophila clock gene drosophila period gene journals search log shirokanedai minato-ku circadian clock system article tei manage preferences messenger rna levels period protein immunoreactivity hypothalamic suprachiasmatic nuclei content pas–pas interaction article purchase kobe university school access

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