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Title[redir]:
Cloning of a new cytokine that induces IFN-γ production by T cells | Nature
Description:
THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely understood1–3, and hitherto unidentified cytokines may be required for the functional maturation of these cells4. Here we report the cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells5,6. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids, which have no obvious similarities to any peptide in the databases. Messenger RNAs for IGIF and interleukin-12 (IL-12) are readily detected in Kupffer cells and activated macrophages. Recombinant IGIF induces IFN-γ more potently than does IL-12, apparently through a separate pathway. Administration of anti-IGIF antibodies prevents liver damage in mice inoculated with Propionibacterium acnes and challenged with lipopolysaccharide, which induces toxic shock. IGIF may be involved in the development of Thl cells and also in mechanisms of tissue injury in inflammatory reactions.
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article, nature, access, google, scholar, cas, cells, content, cookies, japan, privacy, okamura, open, data, induces, tsutsui, komatsu, igif, immune, cell, immun, research, advertising, information, subscribe, cloning, ifnγ, production, interleukin, injury, inflammatory, institution, buy, med, pubmed, press, institute, permissions, optional, media, personal, parties, policy, journals, log, journal, november, cytokine, haruki, hiroko,
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nature portfolio permissions reprints neurochemical research privacy policy subscribe nature advertising il-18-dependent interferon-gamma production nature 378 nature social media induces ifn-γ production development promote balanced effector-regulatory personal data springerlink instant access data protection permissions cells haruki okamura murine liver injury astrocytes responses contribute privacy induces toxic shock alleviating inflammatory damage explore content subscription content european economic area masuo yutsudo akira hakura functionally distinct subsets augments natural killer institutional subscriptions read osaka city university therapeutic targets severe viral pneumonia single nucleotide polymorphisms accepting optional cookies article okamura journals search log hitherto unidentified cytokines issue learn microbial disease immune correlation manage preferences hayashibara biochemical laboratories content article purchase access article cite https 1038/378088a0
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headline:Cloning of a new cytokine that induces IFN-γ production by T cells
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headline:Cloning of a new cytokine that induces IFN-γ production by T cells
description:THE mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Thl and Th2) is incompletely understood1â3, and hitherto unidentified cytokines may be required for the functional maturation of these cells4. Here we report the cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells5,6. The gene encodes a precursor protein of 192 amino acids and a mature protein of 157 amino acids, which have no obvious similarities to any peptide in the databases. Messenger RNAs for IGIF and interleukin-12 (IL-12) are readily detected in Kupffer cells and activated macrophages. Recombinant IGIF induces IFN-γ more potently than does IL-12, apparently through a separate pathway. Administration of anti-IGIF antibodies prevents liver damage in mice inoculated with Propionibacterium acnes and challenged with lipopolysaccharide, which induces toxic shock. IGIF may be involved in the development of Thl cells and also in mechanisms of tissue injury in inflammatory reactions.
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