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We began analyzing https://www.nature.com/articles/370226a0, but it redirected us to https://www.nature.com/articles/370226a0. The analysis below is for the second page.

Title[redir]:
Activation of cAMP and mitogen responsive genes relies on a common nuclear factor | Nature
Description:
A NUMBER of signalling pathways stimulate transcription of target genes through nuclear factors whose activities are primarily regul-ated by phosphorylation. Cyclic AMP regulates the expression of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB at Ser 1331,2. Although phosphorylation may stimulate transcrip-tional activators by modulating their nuclear transport or DNA-binding affinity3, CREB belongs to a class of proteins whose phosphorylation appears specifically to enhance their trans-activation potential1,2,4. Recent work describing a phospho-CREB binding protein (CBP)5 which interacts specifically with the CREB trans-activation domain prompted us to examine whether CBP is neces-sary for cAMP regulated transcription. We report here that micro-injection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter. Surprisingly, CBP also cooperates with upstream activators such as c-Jun, which are involved in mitogen responsive transcription6. We propose that CBP is recruited to the promoter through interaction with certain phosphorylated factors, and that CBP may thus play a critical role in the transmission of inductive signals from cell surface receptor to the transcriptional apparatus.

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article, nature, google, scholar, pubmed, cas, access, cell, karin, transcription, content, cookies, genes, alberts, smeal, privacy, montminy, phosphorylation, cbp, ads, california, data, camp, responsive, nuclear, brindle, feramisco, creb, open, research, advertising, information, subscribe, mitogen, factor, arias, factors, transcriptional, institution, buy, central, jolla, usa, permissions, optional, media, personal, parties, policy, journals,

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nature portfolio permissions reprints privacy policy advertising social media subscribe nature cyclic amp regulates nature 365 nature 353 nature 354 nature 358 nature 351 nature 370 nature stimulate transcrip-tional activators phospho-creb binding protein personal data springerlink instant access data protection permissions dead prey fish privacy transcription factor creb mitogen responsive transcription6 trans-activation potential1 dna-binding affinity3 explore content subscription content mediated phosphorylation european economic area primarily regul-ated recent work describing institutional subscriptions read high-throughput measurements ciba foundation symp clayton foundation laboratories medulloblastoma inna armandariwalderik feeding habit transformation disease prefrontal cortex accepting optional cookies camp regulated transcription journals search log common nuclear factor compact transcriptional effectors phosphorylation appears specifically article purchase manage preferences article cite camp responsive promoter content

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