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Keywords {🔍}

cells, cancer, cik, cell, patients, ciks, article, lung, pubmed, fig, google, scholar, therapy, immunotherapy, group, chemotherapy, treatment, activation, day, cas, tumor, cdcd, clinical, study, nature, medium, cytokineinduced, combination, pbmcs, antibody, supplementary, table, killer, mice, days, anticd, flow, pdl, vitro, expansion, activated, nsclc, mabs, cytometry, size, mgm, data, immune, advanced, effect,

Topics {✒️}

nature portfolio privacy policy index cd3+ cd56+ 1 mm × 1 mm × 1 mm tissue pieces advertising nature 505 nature cytokine-induced killer cell sequential cytokine-induced killer t790m-selective egfr-tki combined cytokine-induced killer cells pd-l1-negative cell line reprints tumor-induced immune suppression cytokine-induced killer jianzhong wu & jifeng feng cancer research 1 μg/ml anti-cd3 mabs clinical research overcoming egfr-tki resistance supplementary table 1 supplementary table 2 adoptive t-cell transfer single-cell rna-seq facsverse/calibur/ariaii- sorp annexin v-fitc anti-cd3 monoclonal antibody anti-cd3 monoclonal antibodies improving anti-cancer abilities small-cell lung cancer pd-1 pathway blockade egfr-tki drug resistance mouse anti‑cd3 antibody human anti-cd3 antibody cytokine-induced killers cord blood-derived b7-h1/pd-1 axis pd-1/pd-l1 immunotherapy development fatal adverse reactions original author disease progression occurred permissions mouse anti-cd3 abs cell death dis supplementary fig social media valproate inhibits growth culture media umbilical cord blood

Questions {❓}

• Immunotherapy improves the prognosis of lung cancer: do we have to change intensive care unit admission and triage guidelines?

Schema {🗺️}

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         description:Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose the opportunity of surgical therapy, most of whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed the role of adoptive T-cell transfer in the maintenance therapy of cancer patients. Here, we provided statistical insights into the role of CIKs in advanced lung cancer from three different levels, cell model (in vitro co-culture system), mice model (in situ lung cancer), and clinical research (in lung cancer patients of different progression stages). We optimized the components of supplements and cytokines on activating and expanding CIK cells. Based on this, we explored a new serum-free medium for in vitro activation and expansion of CIK cells. Moreover, we found that activated CIK cells could efficiently kill lung cancer cells in cell-to-cell model in vitro and significantly reduce the tumor growth in mice. For the clinical research, the OS rates of patients received combination of chemotherapy and CIK treatment were significantly improved compared to the OS rates of patients only received chemotherapy. Additionally, CIK therapy represented good toleration in our study. All the results suggested that combination of immunotherapy with traditional therapy will be a feasible and promising method for the treatment of lung cancer.
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            name:Nanjing Medical University Affiliated Cancer Hospital
            address:
               name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Zhuo Wang
      affiliation:
            name:Nanjing Medical University Affiliated Cancer Hospital
            address:
               name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      name:Jianzhong Wu
      affiliation:
            name:Nanjing Medical University Affiliated Cancer Hospital
            address:
               name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jifeng Feng
      affiliation:
            name:Nanjing Medical University Affiliated Cancer Hospital
            address:
               name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:The Forth Clinical School of Nanjing Medical University, Nanjing, China
      name:Department of Biological Science, Purdue University, West Lafayette, USA
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:The Forth Clinical School of Nanjing Medical University, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China
      name:Research Center of Clinical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China

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