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Title[redir]:
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics
Description:
Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overlap with other autoimmune diseases. To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 Γ 10β8) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.
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headline:Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
description:Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overlap with other autoimmune diseases. To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 ΓΒ 10Γ’ΒΒ8) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.
datePublished:2010-05-09T00:00:00Z
dateModified:2010-05-09T00:00:00Z
pageStart:508
pageEnd:514
sameAs:https://doi.org/10.1038/ng.582
keywords:
Genetic predisposition to disease
Genome-wide association studies
Rheumatoid arthritis
Risk factors
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
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headline:Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
description:Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overlap with other autoimmune diseases. To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 ΓΒ 10Γ’ΒΒ8) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.
datePublished:2010-05-09T00:00:00Z
dateModified:2010-05-09T00:00:00Z
pageStart:508
pageEnd:514
sameAs:https://doi.org/10.1038/ng.582
keywords:
Genetic predisposition to disease
Genome-wide association studies
Rheumatoid arthritis
Risk factors
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
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name:School of Medicine and Biomedical Sciences, Sheffield University, Sheffield, UK
name:Sanquin Research Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
name:Jan van Breemen Institute, Amsterdam, The Netherlands
name:University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
name:Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
name:Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, USA
name:Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
name:Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
name:Celera, Alameda, USA
name:Roche Diagnostics, Pleasanton, USA
name:Arthritis Research UK Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
name:Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Canada
name:The Feinstein Institute for Medical Research, North ShoreΓ’ΒΒLong Island Jewish Health System, Manhasset, USA
name:Department of Medicine, Rheumatology Unit, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
name:Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, USA
name:Broad Institute, Cambridge, USA
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- What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marieke%20J%20H%20Coenen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the revenue for https://www.nature.com/articles/ng.582/search?author=Karen%20H%20Costenbader?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Karen%20H%20Costenbader earns monthly
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- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%20Bart%20A%20Crusius produce monthly?
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- What's the financial intake of https://www.nature.com/articles/ng.582/search?author=Jing%20Cui?
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- Earnings of https://www.nature.com/articles/ng.582/search?author=Paul%20I%20W%20de%20Bakker
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- Get to know what's the income of https://www.nature.com/articles/ng.582/search?author=Bo%20Ding
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- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bo%20Ding%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
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- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20Emery%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Discover the revenue of https://www.nature.com/articles/ng.582/search?author=Edward%20Flynn
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- What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Edward%20Flynn%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.nature.com/articles/ng.582/search?author=Pille%20Harrison generate monthly?
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- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pille%20Harrison%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- Get to know https://www.nature.com/articles/ng.582/search?author=Lynne%20J%20Hocking's earnings
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- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lynne%20J%20Hocking%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Income figures for https://www.nature.com/articles/ng.582/search?author=Tom%20W%20J%20Huizinga
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- What are the earnings of https://www.nature.com/articles/ng.582/search?author=Daniel%20L%20Kastner?
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daniel%20L%20Kastner is on a monthly basis
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- What's the monthly income of https://www.nature.com/articles/ng.582/search?author=Xiayi%20Ke?
- Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xiayi%20Ke
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xiayi%20Ke%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Check the income stats for https://www.nature.com/articles/ng.582/search?author=Annette%20T%20Lee
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Annette%20T%20Lee?
- What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Annette%20T%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
- How much revenue does https://www.nature.com/articles/ng.582/search?author=Xiangdong%20Liu bring in?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xiangdong%20Liu's financial summary
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xiangdong%20Liu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What are the total earnings of https://www.nature.com/articles/ng.582/search?author=Paul%20Martin?
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20Martin
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20Martin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What is the earnings of https://www.nature.com/articles/ng.582/search?author=Ann%20W%20Morgan?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann%20W%20Morgan
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann%20W%20Morgan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- Check the income stats for https://www.nature.com/articles/ng.582/search?author=Leonid%20Padyukov
- Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Leonid%20Padyukov
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Leonid%20Padyukov%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- How much does https://www.nature.com/articles/ng.582/search?author=Marcel%20D%20Posthumus pull in?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marcel%20D%20Posthumus pull in?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marcel%20D%20Posthumus%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- How much does https://www.nature.com/articles/ng.582/search?author=Timothy%20R%20D%20J%20Radstake make?
- What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Timothy%20R%20D%20J%20Radstake?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Timothy%20R%20D%20J%20Radstake%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
- What's the financial outcome of https://www.nature.com/articles/ng.582/search?author=David%20M%20Reid?
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- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22David%20M%20Reid%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
- How much does https://www.nature.com/articles/ng.582/search?author=Mark%20Seielstad make?
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- Explore the financials of https://www.nature.com/articles/ng.582/search?author=Michael%20F%20Seldin
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20F%20Seldin generate?
- What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20F%20Seldin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.nature.com/articles/ng.582/search?author=Nancy%20A%20Shadick pull in?
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- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nancy%20A%20Shadick%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Revenue of https://www.nature.com/articles/ng.582/search?author=Sophia%20Steer
- Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sophia%20Steer
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sophia%20Steer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
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- What is the earnings of https://www.nature.com/articles/ng.582/search?author=Wendy%20Thomson?
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wendy%20Thomson?
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wendy%20Thomson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- Learn how profitable https://www.nature.com/articles/ng.582/search?author=Annette%20H%20M%20van%20der%20Helm-van%20Mil is on a monthly basis
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Annette%20H%20M%20van%20der%20Helm-van%20Mil earns monthly
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Annette%20H%20M%20van%20der%20Helm-van%20Mil%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the financial gain of https://www.nature.com/articles/ng.582/search?author=Irene%20E%20van%20der%20Horst-Bruinsma?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Irene%20E%20van%20der%20Horst-Bruinsma have monthly?
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Irene%20E%20van%20der%20Horst-Bruinsma%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the revenue for https://www.nature.com/articles/ng.582/search?author=C%20Ellen%20van%20der%20Schoot?
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- What is the monthly revenue of https://www.nature.com/articles/ng.582/search?author=Piet%20L%20C%20M%20van%20Riel?
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- Financial intake of https://www.nature.com/articles/ng.582/search?author=Michael%20E%20Weinblatt
- What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20E%20Weinblatt's gross income?
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- Get to know https://www.nature.com/articles/ng.582/search?author=Anthony%20G%20Wilson's earnings
- Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anthony%20G%20Wilson's earnings
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anthony%20G%20Wilson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- What's the profit of https://www.nature.com/articles/ng.582/search?author=Gert%20Jan%20Wolbink?
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- Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gert%20Jan%20Wolbink%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much profit is https://www.nature.com/articles/ng.582/search?author=B%20Paul%20Wordsworth making per month?
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=B%20Paul%20Wordsworth?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22B%20Paul%20Wordsworth%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- How much does https://www.nature.com/articles/ng.582/search?author=Cisca%20Wijmenga pull in monthly?
- How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Cisca%20Wijmenga earning monthly?
- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Cisca%20Wijmenga%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.nature.com/articles/ng.582/search?author=Elizabeth%20W%20Karlson generate monthly?
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Elizabeth%20W%20Karlson?
- Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Elizabeth%20W%20Karlson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much revenue does https://www.nature.com/articles/ng.582/search?author=Rene%20E%20M%20Toes generate?
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rene%20E%20M%20Toes
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rene%20E%20M%20Toes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much income is https://www.nature.com/articles/ng.582/search?author=Niek%20de%20Vries earning monthly?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Niek%20de%20Vries generate?
- Check the income stats for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Niek%20de%20Vries%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's https://www.nature.com/articles/ng.582/search?author=Ann%20B%20Begovich's gross income?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ann%20B%20Begovich's revenue stream
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ann%20B%20Begovich%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- Get to know https://www.nature.com/articles/ng.582/search?author=Jane%20Worthington's earnings
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jane%20Worthington rake in every month?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jane%20Worthington%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
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