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We began analyzing https://link.springer.com/article/10.1023/A:1006263818115, but it redirected us to https://link.springer.com/article/10.1023/A:1006263818115. The analysis below is for the second page.

Title[redir]:
Assessment of quality of life in women undergoing hormonal therapy for breast cancer: validation of an endocrine symptom subscale for the FACT‐B | Breast Cancer Research and Treatment
Description:
Existing quality of life instruments do not include adequate items to measure the side effects and putative benefits of hormonal treatments given in breast cancer. We report the development and validation of an 18 item endocrine subscale (ES) to accompany a standardised breast cancer quality of life measure, the Functional Assessment of Cancer Therapy (FACT‐B) [1]. The FACT‐ES (FACT‐B plus ES) was tested initially on 268 women with breast cancer receiving endocrine treatments. Alpha coefficients for all subscales demonstrated good internal consistency (range α = 0.65–0.87). Test‐retest reliability of the ES indicated good stability (r = 0.93, p < 0.001). Advanced breast cancer patients

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Keywords {🔍}

cancer, breast, endocrine, google, scholar, life, quality, therapy, article, women, patients, research, assessment, symptoms, factb, cella, functional, access, privacy, cookies, content, hormonal, howell, advanced, trial, clin, oncol, publish, search, treatment, factes, reliability, reported, postmenopausal, university, data, information, change, log, journal, validation, symptom, subscale, fallowfield, leaity, treatments, clinical, baseline, validity, open,

Topics {✒️}

patient-reported outcome results month download article/chapter privacy choices/manage cookies related subjects advanced breast cancer full article pdf health-related quality endocrine therapies cancer therapy-breast metastatic breast cancer endocrine therapy persist primary disease reported endocrine symptom subscale cancer therapy-lung hormonal treatments estrogen replacement therapy frequently reported symptoms european economic area include adequate items long-term survivorship van zyl ja health measurement scales randomised trial comparing dose-response trial oxford university press conditions privacy policy accepting optional cookies evanston northwestern healthcare life measurement system breast cancer test‐retest reliability journal finder publish endocrine therapy 2024 endocrine therapy endocrine treatments clinically significant change postmenopausal patients uk lesley cancer therapy cella df check access instant access life access article log anthony howell lung cancer 12 medical oncology fact‐es quality article fallowfield postmenopausal women

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Does the toxicity of endocrine therapy persist into long-term survivorship?

Schema {🗺️}

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         description:Existing quality of life instruments do not include adequate items to measure the side effects and putative benefits of hormonal treatments given in breast cancer. We report the development and validation of an 18 item endocrine subscale (ES) to accompany a standardised breast cancer quality of life measure, the Functional Assessment of Cancer Therapy (FACT‐B) [1]. The FACT‐ES (FACT‐B plus ES) was tested initially on 268 women with breast cancer receiving endocrine treatments. Alpha coefficients for all subscales demonstrated good internal consistency (range α = 0.65–0.87). Test‐retest reliability of the ES indicated good stability (r = 0.93, p < 0.001). Advanced breast cancer patients' quality of life was high, showing the efficacy of endocrine therapy, but women with primary disease reported better physical, social, and functional well‐being and fewer breast cancer concerns. Most frequently reported symptoms were loss of sexual interest (31%), weight gain (25%), and hot flushes (24%). Significant differences were found between treatment groups for hot flushes and vaginal dryness. Two assessments of the instrument's responsiveness to change were made; 32 women in a clinical trial of endocrine therapy and 18 women without breast cancer taking HRT completed the FACT‐ES at baseline, 4, 8, and 12 weeks. Trial patients reported significantly more symptoms at 8 and 12 weeks than at baseline. Women taking HRT reported significantly fewer or less severe symptoms than at baseline. In conclusion the FACT‐ES has acceptable validity and reliability and is sensitive to clinically significant change, making it suitable for clinical trials of endocrine therapy.
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      headline:Assessment of quality of life in women undergoing hormonal therapy for breast cancer: validation of an endocrine symptom subscale for the FACT‐B
      description:Existing quality of life instruments do not include adequate items to measure the side effects and putative benefits of hormonal treatments given in breast cancer. We report the development and validation of an 18 item endocrine subscale (ES) to accompany a standardised breast cancer quality of life measure, the Functional Assessment of Cancer Therapy (FACT‐B) [1]. The FACT‐ES (FACT‐B plus ES) was tested initially on 268 women with breast cancer receiving endocrine treatments. Alpha coefficients for all subscales demonstrated good internal consistency (range α = 0.65–0.87). Test‐retest reliability of the ES indicated good stability (r = 0.93, p < 0.001). Advanced breast cancer patients' quality of life was high, showing the efficacy of endocrine therapy, but women with primary disease reported better physical, social, and functional well‐being and fewer breast cancer concerns. Most frequently reported symptoms were loss of sexual interest (31%), weight gain (25%), and hot flushes (24%). Significant differences were found between treatment groups for hot flushes and vaginal dryness. Two assessments of the instrument's responsiveness to change were made; 32 women in a clinical trial of endocrine therapy and 18 women without breast cancer taking HRT completed the FACT‐ES at baseline, 4, 8, and 12 weeks. Trial patients reported significantly more symptoms at 8 and 12 weeks than at baseline. Women taking HRT reported significantly fewer or less severe symptoms than at baseline. In conclusion the FACT‐ES has acceptable validity and reliability and is sensitive to clinically significant change, making it suitable for clinical trials of endocrine therapy.
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