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We began analyzing https://link.springer.com/article/10.1023/B:JOMG.0000010028.48159.84, but it redirected us to https://link.springer.com/article/10.1023/B:JOMG.0000010028.48159.84. The analysis below is for the second page.

Title[redir]:
Expression Profiling of Human Breast Cancers and Gene Regulation by Progesterone Receptors | Journal of Mammary Gland Biology and Neoplasia
Description:
Even the first expression profiling studies of breast cancers have generated new insights. They suggest for example, that information about tumor aggressiveness, prognosis, metastatic potential, or treatment outcome is encoded in, and can be deduced from, the primary tumor. On the other hand no clinical genomic array data have yet been published that deal with hormonal aspects of breast tumorigenesis, tumor progression, or therapeutics. Rather, studies have focused on experimental model systems. We review below the currently published data on array profiling in clinical breast cancer, then describe our studies in breast cancer cell lines and xenograft models dealing with progesterone receptors (PRs) and the role of progesterone. We demonstrate that the two PR isoforms, PR-A and PR-B, have mostly nonoverlapping molecular signatures when liganded by progesterone, with PR-B the more active form. Additionally, we document the surprising finding that unliganded PRs can regulate gene transcription, with PR-A the more active form. In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. We conclude that in breast cancers, PRs are more than simple markers of estrogen receptor function. Rather, presence of PRs and the ratio of the two isoforms directly influence tumor phenotype, even in the absence of ligand.

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Keywords {🔍}

google, scholar, cancer, breast, expression, progesterone, gene, human, receptor, receptors, analysis, profiling, biol, natl, res, mammary, horwitz, cells, article, van, mol, tumor, usa, molecular, proc, acad, sci, chem, gland, cell, genes, endocrinol, cancers, regulation, sartorius, estrogen, access, function, data, jacobsen, clinical, isoforms, hormone, patterns, dna, nature, genet, factor, privacy, cookies,

Topics {✒️}

ligand-independent gene regulation pr-b-expressing tumors grow month download article/chapter high-density oligonucleotide arrays unique n-terminal segment ecdysone-inducible gene expression light-generated oligonucleotide arrays high-sensitivity array analysis endogenous progestin-sensitive endpoints n-terminal inhibitory function progestin-induced growth inhibition mouse mammary gland microarray-based expression profiling human endometrial glands regulate gene transcription related subjects human progesterone receptors progesterone receptor isoforms estrogen-progestin replacement therapy promoter-specific repressor differential gene regulation gene expression profiling privacy choices/manage cookies full article pdf gene-expression profiles gene expression profiles health initiative investigators epithelial-stromal interactions human progesterone receptor gene expression patterns gene expression revealed gene expression database pr-a-expressing transgenic mice carrying tissue factor expression human breast tumours mammary gland development breast cancer cells human breast cancer mammary gland biology gene expression monitoring progesterone receptor levels limiting factor mediates primary solid tumors human malignancies based gene-expression signature human prostate cancer adjacent breast tumors 11 beta-hydroxysteroid dehydrogenase bcar1/p130cas protein

Schema {🗺️}

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