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We began analyzing https://pubs.acs.org/doi/10.1021/jm070370z, but it redirected us to https://pubs.acs.org/doi/10.1021/jm070370z. The analysis below is for the second page.
Title[redir]:
Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma | Journal of Medicinal Chemistry
Description:
Structure−activity relationship studies centered around 3‘-substituted (Z)-5-(2‘-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume.
Title[redir]:
Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma | Journal of Medicinal Chemistry
Description:
Structure−activity relationship studies centered around 3‘-substituted (Z)-5-(2‘-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume.
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Keywords {🔍}
receptor, glucocorticoid, chemistry, acs, medicinal, synthesis, letters, bioorganic, article, httpsdoiorgjbmcl, access, agonists, robert, nonsteroidal, zhi, information, selective, discovery, keith, marschke, lin, publications, journal, modulators, andrew, liu, dissociated, higuchi, steven, roach, mark, peter, dale, mais, highly, chemical, efficient, molecular, reduced, daniel, hudson, adams, syka, jeffrey, miner, institution, log, options, supporting, vivo,
Topics {✒️}
c2-symmetric bis-isochromenyl sulfones org/page/copyright/permissions andrés negro-vilar acs acs publications 1039/c3ob41962b yi-wei zhu palladium‐catalyzed denitrogenative transannulation silver‐catalyzed intramolecular cyclization 1021/ci500131x ji-chen zhang medicinal chemistry cite acs member benefits acs web editions bilinear linbiexp model nonsteroidal selective modulator chemical information acs publications glucocorticoid receptor binding terms & conditions glucocorticoid response element improving receptor selectivity vitro activity comparable jian-xin ji oxidative oxy -cyclization wen-bin yi louise de grandpre lamphjean yenyongkai limark valdezangie vassarcatalina cuervoe 2-dihydro-9-hydroxy-10-methoxy-2 benchmark data sets babu santha aswani madasamy hari balakrishnan 1039/c9ob00320g nicholas burwick 1007/s00277-018-3465-8 hiromasa yoshioka n-benzyl-n satya narayan sahu partially reduced chromenes jin-long qian yoon joo lee reduced pepck activation combining 3d-qsar mm/pbsa methods predict binding modes wan-ching yen reduced side effects highly regioselective synthesis supporting information efficient heterogeneous catalyst 4-trimethyl-5h-chromeno[3 anti‐inflammatory glucocorticoids acs catalysis 2011 jin-biao liu
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