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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://pubs.acs.org/doi/10.1021/jacs.1c02016, but it redirected us to https://pubs.acs.org/doi/10.1021/jacs.1c02016. The analysis below is for the second page.

Title[redir]:
Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy | Journal of the American Chemical Society
Description:
Precise and lasting immune checkpoint blockade (ICB) therapy with high objective response rate remains a significant challenge in clinical trials. We thus report the development of an aptamer-based logic computing reaction to covalently conjugate immune checkpoint antagonizing aptamers (e.g., aPDL1 aptamer) on the surface of cancer cells, achieving effective and sustained ICB therapy without the need for antibodies. Specifically, azides were metabolically labeled on the cell-surface glycoproteins as “chemical receptors”, enabling cyclooctyne-coupling aPDL1 aptamers to achieve aptamer-based logic computing-mediated azides/cyclooctynes-based bioorthogonal reaction. In stepwise fashion, PDL1 plus azide-bearing glycoproteins are expressed on cells and become multiple inputs in accordance with Boolean logic. Then, if the “AND” conditions of the algorithm are met, cyclooctyne-coupling aptamers are conjugated on the living cell surface, significantly prolonging overall mouse survival by triggering a precise and sustained T cell-mediated antitumor immunotherapy, otherwise not. Our findings indicate that DNA logic computing-mediated cyclooctyne/azide-based bioorthogonal reaction can improve the precision and robustness of ICB therapy, thereby potentially improving the objective response rate.

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is doi.org built with?


Doi.org operates using XENFORO.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 76,079,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

zhang, liu, wang, chen, yang, cancer, acs, dna, huang, journal, cell, immunotherapy, materials, wei, chemical, therapy, checkpoint, immune, tan, chemistry, song, zhao, gao, zhou, aptamerbased, logic, cells, weihong, tumor, shi, httpsdoiorgs, angewandte, chemie, american, article, society, zhu, nano, access, bioorthogonal, shen, imaging, sun, fang, jie, blockade, aptamers, aptamer, surface, pdl,

Topics {✒️}

tls11a-lipo-heng scfv/hip-10 nanocapsules high-throughput biologics-mediated phenotyping tetrazine-responsive isonitrile-caged photosensitiser albumin-binding lipid-aptamer conjugates high pd-l1-expressing tumors pd-1/pd-l1 checkpoint inhibitors programmable melanoma-targeted radio-immunotherapy org/page/copyright/permissions bispecific aptamer-based recognition cell-mediated antitumor immunotherapy dna computation-mediated microfluidics nanomaterial-based fluorescent biosensor multivariate-gated aptamer assemblies aptamer-based biomolecular recognition pyroptosis-mediated chemo-immunotherapy regulating immunoreceptor–ligand interactions coordinative dendrimer-based nanovaccine glowing octopus-inspired nanomachine strain‐free bioorthogonal cycloaddition pd1/pdl1 axis blockade nano-assembly enhances response aptamer-gold nanocage composite pd-l1-targeted imaging target-based drug discovery site-specific photodynamic therapy tissue-engineered heart valve microenvironment-confined kinetic elucidation triple-negative breast cancer activatable cancer photo‐immunotherapy adaptive metal–organic frameworks aptamer‐assisted blockade acs acs publications cyclooctyne-coupling aptamers objective response rate cell-surface glycoproteins azide-bearing glycoproteins covalent lytac enabled living cell surface tumor‐responsive enhancement electrochemical biosensor equipped dna logic circuits adoptive cell therapy aptamer-targeted nanoliposomes dual-mirnas based functional dna materials precisive photodynamic therapy molecular logic gates targeted drug delivery regulating cell autophagy fluorescence-based biosensors

Social Networks {👍}(2)

External Links {🔗}(93)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Hotjar
  • Microsoft Clarity
  • Site Verification - Google

Libraries {📚}

  • Dropzone.js
  • jQuery
  • Knockout.js
  • Particles.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare

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