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Topics {✒️}

eu/docs/en_gb/document_library/epar_-_product_information/human/002604/wc500149671 eu/docs/en_gb/document_library/epar_-_public_assessment_report/human/002604/wc500149673 threonine-protein kinase b-raf braf-mutated high-grade glioma month download article/chapter gov/downloads/drugs/guidances/ucm070246 b-raf-driven tumors braf mutation-positive tumors val600 braf-mutant melanoma braf v600-mutant tumours p450-mediated ddi risk small-cell lung cancer carbon-carbon bond cleavage gov/drugsatfda_docs/nda/2013/202806orig1s000clinpharmr mitogen-activated protein kinase gov/ct2/show/nct02873650 metastatic braf-mutated melanoma braf-mutated metastatic melanoma cyp3a4/2b6/2c inducer benoit blanchet declare braf v600e mutation gov/drugsatfda_docs/label/2018/202806s010lbl trametinib combination therapy marie-noëlle paludetto drug–drug interactions audrey thomas-schoemann wild-type braf mapk-activated protein kinases braf-mutant kinase article puszkiel davies ma etienne chatelut full article pdf combination therapy braf v600 mutations privacy choices/manage cookies drug metab dispos therapeutic drug monitoring drug monitoring unit benoit blanchet dabrafenib-treated melanoma patients health-related quality braf-mutated melanoma raf inhibitors activate falchook gs untreated brain metastases braf inhibitors equal drug interaction potential mol cancer ther pharmacokinetic profile

Questions {❓}

• Paradoxical oncogenesis: are all BRAF inhibitors equal?

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               name:Multidisciplinary Risk Assessment and Drug Monitoring Unit, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
      name:Nora Kramkimel
      affiliation:
            name:Cochin University Hospital, AP-HP
            address:
               name:Department of Dermatology, Cochin University Hospital, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
      name:Marie-Noëlle Paludetto
      affiliation:
            name:Université Paul Sabatier
            address:
               name:Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France
               type:PostalAddress
            type:Organization
            name:Institut Universitaire du Cancer de Toulouse - Oncopole
            address:
               name:Department of Pharmacy, Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, France
               type:PostalAddress
            type:Organization
      name:Audrey Thomas-Schoemann
      affiliation:
            name:CERIA, CARPEM, Cochin University Hospital, AP-HP
            address:
               name:Multidisciplinary Risk Assessment and Drug Monitoring Unit, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
            name:University Paris Descartes, PRES Sorbonne Paris Cité
            address:
               name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
               type:PostalAddress
            type:Organization
      name:Michel Vidal
      affiliation:
            name:University Paris Descartes, PRES Sorbonne Paris Cité
            address:
               name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
               type:PostalAddress
            type:Organization
            name:CERIA, CARPEM, Cochin University Hospital, AP-HP
            address:
               name:Department of Pharmacokinetics and Pharmacochemistry, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
      name:François Goldwasser
      affiliation:
            name:CERIA, CARPEM, Cochin University Hospital, APHP
            address:
               name:Department of Medical Oncology, CERIA, CARPEM, Cochin University Hospital, APHP, Paris, France
               type:PostalAddress
            type:Organization
      name:Etienne Chatelut
      affiliation:
            name:Université Paul Sabatier
            address:
               name:Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France
               type:PostalAddress
            type:Organization
            name:Institut Universitaire du Cancer de Toulouse - Oncopole
            address:
               name:Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, France
               type:PostalAddress
            type:Organization
            name:Groupe de Pharmacologie Clinique Oncologique (GPCO)
            address:
               name:Groupe de Pharmacologie Clinique Oncologique (GPCO), Paris, France
               type:PostalAddress
            type:Organization
      name:Benoit Blanchet
      affiliation:
            name:University Paris Descartes, PRES Sorbonne Paris Cité
            address:
               name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
               type:PostalAddress
            type:Organization
            name:CERIA, CARPEM, Cochin University Hospital, AP-HP
            address:
               name:Department of Pharmacokinetics and Pharmacochemistry, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
               type:PostalAddress
            type:Organization
            name:Groupe de Pharmacologie Clinique Oncologique (GPCO)
            address:
               name:Groupe de Pharmacologie Clinique Oncologique (GPCO), Paris, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France
      name:Department of Pharmacology and Toxicology, Bicetre Hospital, AP-HP, Kremlin Bicetre, France
      name:Department of Medical Oncology, CERIA, CARPEM, Cochin University Hospital, APHP, Paris, France
      name:Multidisciplinary Risk Assessment and Drug Monitoring Unit, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
      name:Department of Dermatology, Cochin University Hospital, AP-HP, Paris, France
      name:Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France
      name:Department of Pharmacy, Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, France
      name:Multidisciplinary Risk Assessment and Drug Monitoring Unit, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
      name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
      name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
      name:Department of Pharmacokinetics and Pharmacochemistry, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
      name:Department of Medical Oncology, CERIA, CARPEM, Cochin University Hospital, APHP, Paris, France
      name:Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France
      name:Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, France
      name:Groupe de Pharmacologie Clinique Oncologique (GPCO), Paris, France
      name:UMR8638 CNRS, Faculty of Pharmacy, University Paris Descartes, PRES Sorbonne Paris Cité, Paris, France
      name:Department of Pharmacokinetics and Pharmacochemistry, CERIA, CARPEM, Cochin University Hospital, AP-HP, Paris, France
      name:Groupe de Pharmacologie Clinique Oncologique (GPCO), Paris, France
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